Reactome | IL2RG [plasma membrane]

IL2RG [plasma membrane]

Stable Identifier

R-HSA-449139

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Cytokine receptor common gamma chain, Interleukin-2 receptor gamma chain, IL2RG_HUMAN, Gamma c

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Locations in the PathwayBrowser for interactor UniProt:Q9NPF0 CD320

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External Reference Information

External Reference

UniProt:P31785 IL2RG

Gene Names

IL2RG

Chain

signal peptide:1-22, chain:23-369

Reference Genes

BioGPS Gene:3561 IL2RG

COSMIC (genes):IL2RG IL2RG

CTD Gene:3561 IL2RG

dbSNP Gene:3561 IL2RG

ENSEMBL:ENSG00000147168 IL2RG

HGNC:6010 IL2RG

KEGG:hsa:3561 IL2RG

Monarch:3561 IL2RG

NCBI Gene:3561 IL2RG

OMIM:308380 IL2RG

UCSC:P31785 IL2RG

Reference Transcript

RefSeq:NM_000206.2 IL2RG

Participates

as an output of

IL2RG gene expression downstream of ALK signaling (Homo sapiens)

as a component of

as an input of

IL2RG binds JAK3 (Homo sapiens)

Other forms of this molecule

p-Y-IL2RG [plasma membrane]

p-Y-IL2RG [cytosol]

IL2RG [endosome]

Inferred To

Ghost homologue of IL2RG [plasma membrane] (Canis familiaris)

Ghost homologue of IL2RG [plasma membrane] (Rattus norvegicus)

IL2RG [plasma membrane] (Bos taurus)

IL2RG [plasma membrane] (Gallus gallus)

IL2RG [plasma membrane] (Sus scrofa)

il13ra2 [plasma membrane] (Danio rerio)

Il2rg [plasma membrane] (Mus musculus)

let-805 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000197.1

Guide to Pharmacology - Targets

2303

OpenTargets

ENSG00000147168

ENSEMBL

ENST00000374202, ENSG00000147168, ENSP00000363318

HPA

ENSG00000147168-IL2RG

GeneCards

IL2RG

PRO

P31785

Pharos - Targets

P31785

Orphanet

IL2RG

GlyGen

P31785

PDB

7S2R, 8EPA, 3BPL, 2B5I, 8ENT, 5M5E, 2ERJ, 6OEL, 4GS7, 3QB7, 3QAZ

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05112 IL4	1	IL4 [extracellular region] (R-HSA-447110)	0.667	3
UniProt:P24394 IL4R	2	p-Y-IL4R [plasma membrane] (R-HSA-6786087) IL4R [plasma membrane] (R-HSA-449670)	0.667	5
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.666	4
UniProt:Q96HR9 REEP6			0.623	3
UniProt:Q6L8G8 KRTAP5-7	1	KRTAP5-7 [cytosol] (R-HSA-6810273)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q9NPF0 CD320	2	CD320 [plasma membrane] (R-HSA-2980909) CD320 E88del [plasma membrane] (R-HSA-3325560)	0.527	2
UniProt:Q9Y5Y0 FLVCR1			0.527	2
UniProt:Q13261 IL15RA	2	IL15RA [endosome] (R-HSA-8983117) IL15RA [plasma membrane] (R-HSA-449122)	0.524	2

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