Signaling by Interleukins

Stable Identifier
Homo sapiens
Signaling by Interleukins and related cytokines
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Interleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but are now known to be produced by many other cells throughout the body. They have pleiotropic effects on cells which bind them, impacting processes such as tissue growth and repair, hematopoietic homeostasis, and multiple levels of the host defense against pathogens where they are an essential part of the immune system.

Literature References
PubMed ID Title Journal Year
19302047 Immunological and inflammatory functions of the interleukin-1 family

Dinarello, CA

Annu Rev Immunol 2009
27577879 Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

Komlosi, Z, Kucuksezer, UC, Frei, R, Huitema, C, Garbani, M, Pezer, M, Olzhausen, J, Stanic, B, Kubo, T, Kovacs, N, Konieczna, P, Hess, L, Ferstl, R, Wawrzyniak, P, Globinska, A, Sugita, K, Eljaszewicz, A, Altunbulakli, C, Meyer, N, Akdis, M, Wanke, K, O'Mahony, L, Costa, RA, Aab, A, Duan, S, Azkur, K, Wawrzyniak, M, Rinaldi, A, Rhyner, C, Zakzuk, JS, Crameri, R, Morita, H, Rebane, A, Wirz, OF, Prati, M, Treis, A, Akdis, CA, Van De Veen, W, Sokolowska, M, Eiwegger, T

J. Allergy Clin. Immunol. 2016
12445398 Interleukin signaling

Vosshenrich, CA, Di Santo, JP

Curr Biol 2002
Event Information
Orthologous Events
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