Signaling by Interleukins

Stable Identifier
R-HSA-449147
Type
Pathway
Species
Homo sapiens
Compartment
Synonyms
Signaling by Interleukins and related cytokines
Locations in the PathwayBrowser
General
Click the image above or here to open this pathway in the Pathway Browser

Interleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but are now known to be produced by many other cells throughout the body. They have pleiotropic effects on cells which bind them, impacting processes such as tissue growth and repair, hematopoietic homeostasis, and multiple levels of the host defense against pathogens where they are an essential part of the immune system.

Literature References
PubMed ID Title Journal Year
27577879 Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

Akdis, M, Aab, A, Altunbulakli, C, Azkur, K, Costa, RA, Crameri, R, Duan, S, Eiwegger, T, Eljaszewicz, A, Ferstl, R, Frei, R, Garbani, M, Globinska, A, Hess, L, Huitema, C, Kubo, T, Komlosi, Z, Konieczna, P, Kovacs, N, Kucuksezer, UC, Meyer, N, Morita, H, Olzhausen, J, O'Mahony, L, Pezer, M, Prati, M, Rebane, A, Rhyner, C, Rinaldi, A, Sokolowska, M, Stanic, B, Sugita, K, Treis, A, Van De Veen, W, Wanke, K, Wawrzyniak, M, Wawrzyniak, P, Wirz, OF, Zakzuk, JS, Akdis, CA

J. Allergy Clin. Immunol. 2016
19302047 Immunological and inflammatory functions of the interleukin-1 family

Dinarello, CA

Annu Rev Immunol 2009
12445398 Interleukin signaling

Vosshenrich, CA, Di Santo, JP

Curr Biol 2002
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created