Reactome | MAP3K11 [cytosol]

MAP3K11 [cytosol]

Stable Identifier

R-HSA-449607

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MLK3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q16584 MAP3K11

Gene Names

MAP3K11, MLK3, PTK1, SPRK

Chain

chain:1-847

Reference Genes

BioGPS Gene:4296 MAP3K11

COSMIC (genes):MAP3K11 MAP3K11

CTD Gene:4296 MAP3K11

dbSNP Gene:4296 MAP3K11

ENSEMBL:ENSG00000173327 MAP3K11

ENSEMBL_homo_sapiens_GENE:ENSG00000173327.8 MAP3K11

HGNC:6850 MAP3K11

KEGG Gene (Homo sapiens):4296 MAP3K11

Monarch:4296 MAP3K11

NCBI Gene:4296 MAP3K11

OMIM:600050 MAP3K11

UCSC:Q16584 MAP3K11

Reference Transcript

RefSeq:NM_002419.3 MAP3K11

Other Identifiers

11719793_a_at

11746632_a_at

1397_at

1398_g_at

16740469

203652_PM_at

203652_at

3377753

3377754

3377755

3377756

3377757

3377758

3377763

3377764

3377766

3377768

3377769

3377770

3377772

3377774

3377776

3377777

3377778

3377779

4296

7949454

A_23_P98275

A_33_P3301851

GE79298

GO:0000165

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004706

GO:0004709

GO:0005515

GO:0005524

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0006468

GO:0007017

GO:0007254

GO:0012501

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0031267

GO:0031434

GO:0031435

GO:0036211

GO:0042802

GO:0042803

GO:0043065

GO:0043226

GO:0043507

GO:0043525

GO:0044843

GO:0046330

GO:0046777

GO:0106310

GO:0140096

HMNXSV003028859

ILMN_1651788

L32976_at

PH_hs_0025256

TC11001938.hg

g4505194_3p_at

Participates

as a candidate of

RHOV effectors [cytosol] (Homo sapiens)

as a member of

This entity regulates

Positively

Inferred To

MAP3K11 [cytosol] (Bos taurus)

MAP3K11 [cytosol] (Caenorhabditis elegans)

MAP3K11 [cytosol] (Canis familiaris)

MAP3K11 [cytosol] (Drosophila melanogaster)

MAP3K11 [cytosol] (Mus musculus)

MAP3K11 [cytosol] (Rattus norvegicus)

MAP3K11 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_002410.1

ZINC - World Drugs

M3K11_HUMAN

Guide to Pharmacology - Targets

2071

OpenTargets

ENSG00000173327

ZINC - FDA approved

M3K11_HUMAN

ZINC - Substances

M3K11_HUMAN

ZINC - Biogenic

M3K11_HUMAN

ZINC target

Q16584

PRO

Q16584

PDB

5K28, 6CQ7, 6AQB, 5K26

ZINC - Investigational

M3K11_HUMAN

GeneCards

Q16584

HPA

ENSG00000173327-MAP3K11

Ensembl

ENST00000530153, ENSG00000173327, ENSP00000433886, ENST00000309100, ENSP00000309597

Pharos - Targets

Q16584

ZINC - Predictions - Purchasable

M3K11_HUMAN

HMDB Protein

HMDBP08747

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.645	4
UniProt:Q99IB8-PRO_0000045602			0.61	5
UniProt:P06930 VE6			0.547	2
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.536	3
UniProt:P70218 M4K1			0.508	3
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.462	3

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