IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2

Stable Identifier
R-HSA-449811
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Interleukin-10 receptor chain B (IL10RB, IL10R2, CRF2-4) binds the IL1-10:IL10RA complex, causing conformational changes that allow it to bind IL-10 (Yoon et al. 2010). IL10RB is essential for signal transduction (Kotenko et al. 1997). It is constitutively bound to the JAK family kinase TYK2 (Kotenko et al. 1997, Spencer et al. 1998).

IL10RB can also combine with either IL-22R1, IFN-lambdaR1 or IL-20R1 to assemble the IL-22, IFN-lambda or IL-26 receptor complexes, respectively (Kotenko & Langer 2004).

Literature References
PubMed ID Title Journal Year
9312047 Identification and functional characterization of a second chain of the interleukin-10 receptor complex

Kotenko, SV, Krause, CD, Izotova, LS, Pollack, BP, Wu, W, Pestka, S

EMBO J 1997
16982608 Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex

Yoon, SI, Logsdon, NJ, Sheikh, F, Donnelly, RP, Walter, MR

J. Biol. Chem. 2006
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