IL13 binds IL13RA2

Stable Identifier
R-HSA-449818
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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IL13 binds IL13RA2
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Interleukin-13 receptor alpha 2 (IL13RA2), sometimes called Interleukin-13 binding protein (IL13BP) is a high affinity receptor for IL13 (Kd = 250 pmol/L) but is not sufficient to render cells responsive to IL13, even in the presence of IL4R (Donaldson et al. 1998). It is reported to exist in soluble form (Zhang et al. 1997); overexpression reduces STAT6 signaling (Kawakami et al. 2001). Its function may be to prevent IL13 signaling via the functional IL4R:IL13RA1 cell surface receptor. IL13BP is overexpressed in some human cancers and enhances cell invasion (Joshi & Puri 2012).
Literature References
PubMed ID Title Journal Year
8663118 Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain

Laurent, P, Vita, N, Caput, D, Lefort, S, Ferrara, P, Kaghad, M, Lelias, JM

J Biol Chem 1996
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Orthologous Events
IL13 binds IL13RA2 (Bos taurus)
IL13 binds IL13RA2 (Canis familiaris)
IL13 binds IL13RA2 (Mus musculus)
IL13 binds IL13RA2 (Rattus norvegicus)
IL13 binds IL13RA2 (Sus scrofa)
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2009-12-07)
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