Other interleukin signaling

Stable Identifier
R-HSA-449836
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
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Summation

Interleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but are now known to be produced by many other cells throughout the body. They have pleiotropic effects on cells which bind them, impacting processes such as tissue growth and repair, hematopoietic homeostasis, and multiple levels of the host defense against pathogens where they are an essential part of the immune system.

Literature References
PubMed ID Title Journal Year
21377040 Interleukins, from 1 to 37, and interferon-?: receptors, functions, and roles in diseases J. Allergy Clin. Immunol. 2011
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
cytokine-mediated signaling pathway (0019221)
Orthologous Events
Other interleukin signaling (Arabidopsis thaliana)
Other interleukin signaling (Bos taurus)
Other interleukin signaling (Caenorhabditis elegans)
Other interleukin signaling (Canis familiaris)
Other interleukin signaling (Danio rerio)
Other interleukin signaling (Drosophila melanogaster)
Other interleukin signaling (Gallus gallus)
Other interleukin signaling (Mus musculus)
Other interleukin signaling (Oryza sativa)
Other interleukin signaling (Rattus norvegicus)
Other interleukin signaling (Sus scrofa)
Other interleukin signaling (Taeniopygia guttata)
Other interleukin signaling (Xenopus tropicalis)
Authored
Jupe, Steve, 2014-06-04
Reviewed
Meldal, Birgit, 2016-01-28