acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]

Stable Identifier
R-HSA-449911
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ACSS1 (acyl-CoA synthetase short-chain family member 1) in the mitochondrial matrix catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Schwer et al. 2006).

Literature References
PubMed ID Title Journal Year
16788062 Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

Schwer, B, Bunkenborg, J, Verdin, RO, Andersen, JS, Verdin, E

Proc Natl Acad Sci U S A 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acetate-CoA ligase activity of ACSS1 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created