pyrophosphate + H2O => 2 orthophosphate [mitochondrial]

Stable Identifier
R-HSA-449937
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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Mitochondrial PPA2 (pyrophosphatase (inorganic) 2) catalyzes the hydrolysis of pyrophosphate to yield two molecules of orthophosphate. The enzyme requires Mg++ for activity (Curbo et al. 2006). The enzyme is inferred to be a homodimer by analogy to its cytosolic isoform.

Literature References
PubMed ID Title Journal Year
16300924 Human mitochondrial pyrophosphatase: cDNA cloning and analysis of the gene in patients with mtDNA depletion syndromes

Curbo, S, Lagier-Tourenne, C, Carrozzo, R, Palenzuela, L, Lucioli, S, Hirano, M, Santorelli, F, Arenas, J, Karlsson, A, Johansson, M

Genomics 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inorganic diphosphatase activity of PPA2 dimer [mitochondrial matrix]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created