IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)

Stable Identifier
R-HSA-449976
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Interleukin-11 receptor alpha:Interleukin-11 binds Interleukin-6 receptor beta
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Interleukin-11 receptor alpha subunit (IL11RA) binds interleukin-11 (IL11) with low affinity but for high affinity binding and signaling must associate with interleukin-6 receptor beta subunit (IL6ST, gp130).

Literature References
PubMed ID Title Journal Year
8637716 The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor

Nandurkar, HH, Hilton, DJ, Nathan, P, Willson, T, Nicola, N, Begley, CG

Oncogene 1996
7957045 Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction

Hilton, DJ, Hilton, AA, Raicevic, A, Rakar, S, Harrison-Smith, M, Gough, NM, Begley, CG, Metcalf, D, Nicola, NA, Willson, TA

EMBO J 1994
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