Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta

Stable Identifier
R-HSA-450027
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The crystal structure of the assembled IL2:IL2 receptor complex and experiments using isothermal titration calorimetry suggest that the complex of IL2 with IL2R alpha is likely to preferentially associate with IL2R bet (Rickert et al. 2004, Stauber et al. 2006). Binding of IL-2/IL-2R alpha to IL-2R beta significantly slows the dissociation of IL-2. However, the trimeric complex of IL-2:IL-2R alpha:IL-2R beta is incapable of signaling without participation of the gamma chain.

Literature References
PubMed ID Title Journal Year
15178252 Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its alpha, beta, and gamma(c) receptors

Rickert, M, Boulanger, MJ, Goriatcheva, N, Garcia, KC

J Mol Biol 2004
16477002 Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor

Stauber, DJ, Debler, EW, Horton, PA, Smith, KA, Wilson, IA

Proc Natl Acad Sci U S A 2006
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