Reactome | Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta

Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta

Stable Identifier

R-HSA-450027

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta

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The crystal structure of the assembled IL2:IL2 receptor complex and experiments using isothermal titration calorimetry suggest that the complex of IL2 with IL2R alpha is likely to preferentially associate with IL2R bet (Rickert et al. 2004, Stauber et al. 2006). Binding of IL-2/IL-2R alpha to IL-2R beta significantly slows the dissociation of IL-2. However, the trimeric complex of IL-2:IL-2R alpha:IL-2R beta is incapable of signaling without participation of the gamma chain.

Literature References

PubMed ID	Title	Journal	Year
16477002	Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor Stauber, DJ, Horton, PA, Debler, EW, Smith, KA, Wilson, IA	Proc Natl Acad Sci U S A	2006
15178252	Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its alpha, beta, and gamma(c) receptors Goriatcheva, N, Boulanger, MJ, Rickert, M, Garcia, KC	J Mol Biol	2004