Reactome: A Curated Pathway Database

Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2

Stable Identifier
R-HSA-450031
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The alpha subunit of the IL3 receptor binds IL 3 with low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex is then able to bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008). Covalent linkage of the receptor subunits is required for receptor signalling (Stomski et al. 1996).

Literature References
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