Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit

Stable Identifier
R-HSA-450063
Type
Reaction
Species
Homo sapiens
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Recruitment of the IL-2R gamma chain forms a very stable quaternary complex, capable of signaling. The IL-2 gamma chain further retards IL-2 dissociation so that the rate of IL-2 dissociation from the complex is three times slower than the rate of internalization of the complex (t1/2 55= 45 min vs. 15 min). Therefore, the complex continues to signal as long as it remains on the cell surface.

Literature References
PubMed ID Title Journal Year
15178252 Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its alpha, beta, and gamma(c) receptors

Rickert, M, Boulanger, MJ, Goriatcheva, N, Garcia, KC

J Mol Biol 2004
16477002 Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor

Stauber, DJ, Debler, EW, Horton, PA, Smith, KA, Wilson, IA

Proc Natl Acad Sci U S A 2006
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