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IL5RA [plasma membrane]
Stable Identifier
R-HSA-450072
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-5 receptor subunit alpha, IL5RA_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Activation of STAT5a/b by JAK2 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
IL3RB is phosphorylated on Ser-585 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin-5 receptor alpha subunit binds Interleukin-5 (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
JAK2 is phosphorylated, activated (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
SHC1 bound to the common beta chain becomes tyrosine phosphorylated (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
SHP1 and SHP2 bind the common beta chain (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
STAT5 is recruited by JAK2 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
The receptor is activated (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Tyrosine kinases phosphorylate the receptor (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
p-STAT5 dissociates from the receptor complex (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
IL5RA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01344 IL5RA
Gene Names
IL5RA, IL5R
Chain
signal peptide:1-20, chain:21-420
Reference Genes
COSMIC (genes):IL5RA IL5RA
dbSNP Gene:3568 IL5RA
ENSEMBL:ENSG00000091181 IL5RA
Participates
as an input of
Interleukin-5 receptor alpha subunit binds Interleukin-5 (Homo sapiens)
as a component of
IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)
Inferred To
Il5ra [plasma membrane]
(Mus musculus)
IL5RA [plasma membrane]
(Bos taurus)
IL5RA [plasma membrane]
(Canis familiaris)
IL5RA [plasma membrane]
(Gallus gallus)
IL5RA [plasma membrane]
(Sus scrofa)
Ghost homologue of IL5RA [plasma membrane]
(Rattus norvegicus)
let-805 [plasma membrane]
(Caenorhabditis elegans)
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32927 CSF2RB
6
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
CSF2RB [plasma membrane]
(R-HSA-879960)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
0.589
3
UniProt:P05113 IL5
1
IL5 [extracellular region]
(R-HSA-447159)
0.524
2
UniProt:O60674 JAK2
8
JAK2 [cytosol]
(R-HSA-210620)
p-Y1007-JAK2 [cytosol]
(R-HSA-873799)
p-12Y-JAK2 [cytosol]
(R-HSA-2586516)
JAK2 [endosome lumen]
(R-HSA-2002372)
JAK2 V617F [nucleoplasm]
(R-HSA-5211269)
p-Y813-JAK2 [cytosol]
(R-HSA-997248)
p-JAK2 [cytosol]
(R-HSA-210621)
p-Y1007,Y1008-JAK2 [cytosol]
(R-HSA-9005327)
0.499
2
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