Reactome | IL5RA [plasma membrane]

IL5RA [plasma membrane]

Stable Identifier

R-HSA-450072

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-5 receptor subunit alpha, IL5RA_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O60674%20JAK2

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External Reference Information

External Reference

UniProt:Q01344 IL5RA

Gene Names

IL5RA, IL5R

Chain

signal peptide:1-20, chain:21-420

Reference Genes

BioGPS Gene:3568 IL5RA

COSMIC (genes):IL5RA IL5RA

CTD Gene:3568 IL5RA

dbSNP Gene:3568 IL5RA

ENSEMBL:ENSG00000091181 IL5RA

ENSEMBL_homo_sapiens_GENE:ENSG00000091181.20 IL5RA

HGNC:6017 IL5RA

KEGG Gene (Homo sapiens):3568 IL5RA

Monarch:3568 IL5RA

NCBI Gene:3568 IL5RA

OMIM:147851 IL5RA

UCSC:Q01344 IL5RA

Reference Transcript

Other Identifiers

11734541_a_at

11738838_a_at

11740816_a_at

11753566_a_at

16950216

207902_PM_at

207902_at

210744_PM_s_at

210744_s_at

211516_PM_at

211516_at

211517_PM_s_at

211517_s_at

2660609

2660610

2660612

2660614

2660616

2660618

2660619

2660620

2660622

2660624

2660626

2660627

2660628

2660630

2660631

2660632

2660633

2660634

2660635

2660636

2660637

2660638

2660640

2660641

2660642

3568

36755_s_at

8085062

A_23_P109843

A_23_P500676

A_32_P177500

A_33_P3328254

GE502399

GE80844

GE845078

GO:0002376

GO:0002437

GO:0004896

GO:0004914

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006954

GO:0007165

GO:0009897

GO:0016020

GO:0019221

GO:0019955

GO:0023052

GO:0032674

GO:0038043

GO:0043235

GO:0060089

GO:0070665

GO:0071310

HMNXSV003031343

HMNXSV003038037

ILMN_1756455

ILMN_2327812

PH_hs_0004089

TC03001122.hg

g10835130_3p_at

g186342_3p_at

g186387_3p_a_at

Participates

as an input of

Interleukin-5 receptor alpha subunit binds Interleukin-5 (Homo sapiens)

as a component of

IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)

Inferred To

Il5ra [plasma membrane] (Mus musculus)

IL5RA [plasma membrane] (Bos taurus)

IL5RA [plasma membrane] (Canis familiaris)

IL5RA [plasma membrane] (Gallus gallus)

IL5RA [plasma membrane] (Sus scrofa)

Ghost homologue of IL5RA [plasma membrane] (Rattus norvegicus)

let-805 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000555.2, NP_783851.1, NP_783855.1, NP_783853.1, NP_001230028.1, NP_783854.1, NP_783852.1

Guide to Pharmacology - Targets

1706

OpenTargets

ENSG00000091181

GeneCards

Q01344

HPA

ENSG00000091181-IL5RA

Ensembl

ENSP00000309196, ENSG00000091181, ENST00000438560, ENST00000256452, ENST00000456302, ENST00000430514, ENST00000446632, ENST00000383846, ENST00000311981, ENSP00000400400, ENSP00000390753, ENSP00000392059, ENSP00000256452, ENSP00000412209, ENSP00000373358

PRO

Q01344

Pharos - Targets

Q01344

PDB

6H41, 1OBZ, 3QT2, 1OBX, 3VA2

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32927 CSF2RB	6	CSF2RB S271L [plasma membrane] (R-HSA-5688879) p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) CSF2RB [plasma membrane] (R-HSA-879960) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863)	0.589	3
UniProt:P05113 IL5	1	IL5 [extracellular region] (R-HSA-447159)	0.524	2
UniProt:O60674 JAK2	8	p-Y1007,Y1008-JAK2 [cytosol] (R-HSA-9005327) p-JAK2 [cytosol] (R-HSA-210621) p-Y813-JAK2 [cytosol] (R-HSA-997248) JAK2 V617F [nucleoplasm] (R-HSA-5211269) JAK2 [endosome lumen] (R-HSA-2002372) p-12Y-JAK2 [cytosol] (R-HSA-2586516) p-Y1007-JAK2 [cytosol] (R-HSA-873799) JAK2 [cytosol] (R-HSA-210620)	0.499	2

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