Reactome | IL5RA [plasma membrane]

IL5RA [plasma membrane]

Stable Identifier

R-HSA-450072

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-5 receptor subunit alpha, IL5RA_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P05113 IL5

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External Reference Information

External Reference

UniProt:Q01344 IL5RA

Gene Names

IL5RA, IL5R

Chain

signal peptide:1-20, chain:21-420

Reference Genes

BioGPS Gene:3568 IL5RA

COSMIC (genes):IL5RA IL5RA

CTD Gene:3568 IL5RA

dbSNP Gene:3568 IL5RA

ENSEMBL:ENSG00000091181 IL5RA

HGNC:6017 IL5RA

KEGG:hsa:3568 IL5RA

Monarch:3568 IL5RA

NCBI Gene:3568 IL5RA

OMIM:147851 IL5RA

UCSC:Q01344 IL5RA

Reference Transcript

Participates

as an input of

Interleukin-5 receptor alpha subunit binds Interleukin-5 (Homo sapiens)

as a component of

IL5 homodimer:IL5RA [plasma membrane] (Homo sapiens)

Inferred To

Il5ra [plasma membrane] (Mus musculus)

IL5RA [plasma membrane] (Bos taurus)

IL5RA [plasma membrane] (Canis familiaris)

IL5RA [plasma membrane] (Gallus gallus)

IL5RA [plasma membrane] (Sus scrofa)

Ghost homologue of IL5RA [plasma membrane] (Rattus norvegicus)

let-805 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_783855.1, NP_783854.1, NP_783853.1, NP_001230028.1, NP_000555.2, NP_783851.1, NP_783852.1

Guide to Pharmacology - Targets

1706

OpenTargets

ENSG00000091181

ENSEMBL

ENSG00000091181, ENSP00000373358, ENST00000430514, ENST00000256452, ENST00000383846, ENSP00000256452, ENST00000456302, ENSP00000400400, ENSP00000309196, ENST00000311981, ENST00000446632, ENSP00000390753, ENSP00000392059, ENSP00000412209, ENST00000438560

HPA

ENSG00000091181-IL5RA

GeneCards

IL5RA

PRO

Q01344

Pharos - Targets

Q01344

GlyGen

Q01344

PDB

6H41, 1OBX, 1OBZ, 3VA2, 3QT2, 8TLD

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32927 CSF2RB	6	p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) CSF2RB [plasma membrane] (R-HSA-879960) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863) CSF2RB S271L [plasma membrane] (R-HSA-5688879)	0.589	3
UniProt:P05113 IL5	1	IL5 [extracellular region] (R-HSA-447159)	0.524	2
UniProt:O60674 JAK2	8	JAK2 [cytosol] (R-HSA-210620) p-Y1007-JAK2 [cytosol] (R-HSA-873799) p-12Y-JAK2 [cytosol] (R-HSA-2586516) JAK2 [endosome lumen] (R-HSA-2002372) JAK2 V617F [nucleoplasm] (R-HSA-5211269) p-Y813-JAK2 [cytosol] (R-HSA-997248) p-JAK2 [cytosol] (R-HSA-210621) p-Y1007,Y1008-JAK2 [cytosol] (R-HSA-9005327)	0.499	2

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