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p-S189,T193-MAP2K3 [nucleoplasm]
Stable Identifier
R-HSA-450229
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S189,T193-MKK3, Mitogen-activated protein kinase kinase 3 (phosphorylated)
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S189,T193-MAP2K3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P46734 MAP2K3
Gene Names
MAP2K3, MEK3, MKK3, PRKMK3, SKK2
Chain
chain:1-347
Reference Genes
BioGPS Gene:5606 MAP2K3
COSMIC (genes):MAP2K3 MAP2K3
CTD Gene:5606 MAP2K3
dbSNP Gene:5606 MAP2K3
ENSEMBL:ENSG00000034152 MAP2K3
HGNC:6843 MAP2K3
KEGG Gene (Homo sapiens):5606 MAP2K3
Monarch:5606 MAP2K3
NCBI Gene:5606 MAP2K3
OMIM:602315 MAP2K3
UCSC:P46734 MAP2K3
Reference Transcript
RefSeq:XM_017024858.1 MAP2K3
RefSeq:XM_017024859.1 MAP2K3
RefSeq:NM_001316332.1 MAP2K3
RefSeq:NM_145109.2 MAP2K3
RefSeq:NM_002756.4 MAP2K3
RefSeq:XM_011523959.1 MAP2K3
RefSeq:XM_005256723.2 MAP2K3
Other Identifiers
0004590114
0007100154
0007100750
11742801_a_at
1622_at
16832268
18548
2075_s_at
207667_s_at
215498_s_at
215499_at
3714730
3714731
3714733
3714735
3714744
3714745
3714748
3714749
3714751
3714752
3714753
3714754
3714755
3714758
3714759
3714764
3714766
3714767
3714768
3714769
3714770
3714772
5606
8005707
A_14_P109219
A_23_P118427
A_24_P296698
AAB40652
AAB40653
AAC41718
AAH32478
AB451226
AB451349
AK093838
AK315505
BAA13248
BAG37889
BAG52769
BAG70040
BAG70163
BC032478
CAB018548
CAG38752
CCDS11217
CCDS11218
CR536514
D87116
D87116_at
E9PMA8
E9PRZ0
ENSG00000034152
ENSP00000319139
ENSP00000345083
ENSP00000355081
ENSP00000478619
ENST00000316920
ENST00000316920.10
ENST00000342679
ENST00000342679.8
ENST00000361818
ENST00000361818.9
ENST00000613338
ENST00000613338.4
EntrezGene:5606
EntrezGene:MAP2K3
g4506098_3p_a_at
GE594548
GE62082
GO:0000165
GO:0000166
GO:0000187
GO:0003013
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0004713
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0006950
GO:0006954
GO:0007165
GO:0008150
GO:0009058
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019899
GO:0019901
GO:0023014
GO:0032147
GO:0034641
GO:0035924
GO:0038066
GO:0040011
GO:0042035
GO:0043167
GO:0043226
GO:0043536
GO:0045860
GO:0045893
GO:0048870
GO:0060048
HGNC:6843
Hs.180533.2.S1_3p_a_at
Hs.180533.2.S1_3p_x_at
ILMN_1668909
ILMN_1680777
ILMN_1790534
IPR000719
IPR008271
IPR011009
IPR017441
J3KRV4
J3QL77
J3QR49
L36719
MAP2K3
MAP2K3-201
MAP2K3-202
MAP2K3-203
MAP2K3-214
MIM:602315
NM_001316332
NM_002756
NM_145109
NP_001303261
NP_002747
NP_659731
PF00069
PH_hs_0010680
Q6FI23
SM00220
TC17000297.hg
TC17002123.hg
U66839
U66840
UPI000002AE41
UPI000012F48C
X6RB39
XM_005256723
XM_011523958
XM_011523959
XM_017024857
XM_017024858
XM_017024859
XP_005256780
XP_011522260
XP_011522261
XP_016880346
XP_016880347
XP_016880348
Participant Of
hasMember
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm]
Other forms of this molecule
MAP2K3 [cytosol]
p-S189,T193-MAP2K3 [cytosol]
Inferred To
Homologues of p-S189,T193-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Bos taurus)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Canis familiaris)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Danio rerio)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Dictyostelium discoideum)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Drosophila melanogaster)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Mus musculus)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Plasmodium falciparum)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Rattus norvegicus)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Schizosaccharomyces pombe)
phospho-p-S189,T193-MAP2K3 [nucleoplasm] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 189
Coordinate
189
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 193
Coordinate
193
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
ZINC - Investigational
MP2K3_HUMAN
RefSeq
XP_011522261.1
,
NP_002747.2
,
XP_016880348.1
,
NP_001303261.1
,
XP_016880347.1
,
NP_659731.1
,
XP_005256780.1
ZINC - World Drugs
MP2K3_HUMAN
OpenTargets
ENSG00000034152
ZINC - FDA approved
MP2K3_HUMAN
GeneCards
P46734
ZINC - Substances
MP2K3_HUMAN
ZINC - Biogenic
MP2K3_HUMAN
ZINC target
P46734
PRO
P46734
ZINC - Predictions - Purchasable
MP2K3_HUMAN
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.688
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.589
5
UniProt:Q16539 MAPK14
7
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [nucleoplasm]
(R-HSA-446223)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
0.564
2
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