Reactome | p-T69,T71-ATF2 [nucleoplasm]

p-T69,T71-ATF2 [nucleoplasm]

Stable Identifier

R-HSA-450243

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cyclic AMP-dependent transcription factor ATF-2 (phosphorylated)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P15336 ATF2

Gene Names

ATF2, CREB2, CREBP1

Chain

chain:1-505

Reference Genes

BioGPS Gene:1386 ATF2

COSMIC (genes):ATF2 ATF2

CTD Gene:1386 ATF2

dbSNP Gene:1386 ATF2

ENSEMBL:ENSG00000115966 ATF2

HGNC:784 ATF2

KEGG Gene (Homo sapiens):1386 ATF2

Monarch:1386 ATF2

NCBI Gene:1386 ATF2

OMIM:123811 ATF2

UCSC:P15336 ATF2

Reference Transcript

Other Identifiers

0002680035

11739868_a_at

11750233_a_at

11750480_a_at

11761942_at

11763586_s_at

1386

1555146_at

16905322

1994_at

205446_s_at

212984_at

2588067

2588068

2588069

2588070

2588071

2588072

2588073

2588075

2588080

2588081

2588082

2588086

2588091

2588092

2588093

2588094

2588095

2588096

2588098

2588099

2588103

2588104

2588106

2588107

2588112

2588113

2588114

2588115

2588116

37575_at

38902_r_at

8056909

A_23_P209879

A_24_P128145

A_24_P246467

GE56268

GE81083

GO:0000122

GO:0000228

GO:0000278

GO:0000790

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001102

GO:0001228

GO:0003151

GO:0003674

GO:0003676

GO:0003677

GO:0003682

GO:0003700

GO:0004402

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005741

GO:0006355

GO:0006357

GO:0006464

GO:0006810

GO:0006950

GO:0006970

GO:0006974

GO:0007005

GO:0007049

GO:0008134

GO:0008140

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0009414

GO:0010628

GO:0016020

GO:0016525

GO:0016573

GO:0016740

GO:0016746

GO:0019899

GO:0019901

GO:0030154

GO:0031573

GO:0032915

GO:0034641

GO:0035497

GO:0035861

GO:0043167

GO:0043226

GO:0043525

GO:0043565

GO:0044877

GO:0045444

GO:0045944

GO:0046872

GO:0048646

GO:0048856

GO:0050680

GO:0051090

GO:0051091

GO:0051276

GO:0060612

GO:0061024

GO:0097186

GO:0110024

GO:1902110

Hs.80285.0.S1_3p_at

Hs2.198166.2.S1_3p_at

Hs2.198166.2.S1_3p_x_at

ILMN_1748271

PH_hs_0022193

TC02002545.hg

TC02004705.hg

X15875_at

g4503032_3p_a_at

Participant Of

input

hasComponent

hasMember

p-S63 ATF1,p-T69, T71 ATF2 [nucleoplasm]

output

Phosphorylated MAPKs phosphorylate ATF-2

This entity regulates

Positively

Expression of PPARGC1A (PGC-1alpha)

Other forms of this molecule

ATF2 [nucleoplasm]

Inferred To

phospho-p-T69,T71-ATF2 [nucleoplasm] (Bos taurus)

phospho-ATF2 [nucleoplasm] (Canis familiaris)

phospho-ATF2 [nucleoplasm] (Gallus gallus)

phospho-ATF2 [nucleoplasm] (Sus scrofa)

phospho-Atf-2 [nucleoplasm] (Drosophila melanogaster)

phospho-atf-7 [nucleoplasm] (Caenorhabditis elegans)

phospho-Atf2 [nucleoplasm] (Mus musculus)

phospho-Atf2 [nucleoplasm] (Rattus norvegicus)

phospho-SKO1 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-atf1 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-ACA1 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of p-T69,T71-ATF2 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of p-T69,T71-ATF2 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-atf2 [nucleoplasm] (Danio rerio)

phospho-atf2 [nucleoplasm] (Xenopus tropicalis)

phospho-atf21 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-atf31 [nucleoplasm] (Schizosaccharomyces pombe)

Modified Residues

Name

O-phospho-L-threonine at 71

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 69

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001871.2, NP_001243019.1, NP_001243023.1, NP_001243022.1, NP_001243020.1, NP_001243021.1

OpenTargets

ENSG00000115966

GeneCards

P15336

HPA

ENSG00000115966-ATF2

Ensembl

ENSP00000386526, ENSP00000376327, ENST00000392544, ENSG00000115966, ENST00000409499, ENSP00000387093, ENSP00000407911, ENST00000264110, ENST00000345739, ENSP00000386282, ENSP00000340576, ENST00000426833, ENSP00000264110, ENST00000409635, ENST00000409833

PRO

P15336

HMDB Protein

HMDBP08112

PDB

1T2K, 4H36, 1BHI

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.929	16
UniProt:P01100 FOS	2	p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283) FOS [nucleoplasm] (R-HSA-450216)	0.872	11
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.781	9
UniProt:P15408 FOSL2			0.756	6
UniProt:P63165 SUMO1	155	TOPORS-G97-SUMO1 [nucleoplasm] (R-HSA-4551623) K14-UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-4085334) PIAS4-G97-SUMO1 [nucleoplasm] (R-HSA-3968375) K2592-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551627) K2723-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551737) K2650-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551591) K196-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551630) K171-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551632) K159-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551713) MDM-G97-SUMO1 [nucleoplasm] (R-HSA-3730829) K575-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090305) K804-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782561) K750-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090298) K676-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090396) K554-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782555) K779-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782585) ING2-G97-SUMO1 [nucleoplasm] (R-HSA-4086096) K788-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085297) K731-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085312) K239-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085320) K239-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085299) K731-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085290) K788-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085308) NPM1-G97-SUMO1 [nucleoplasm] (R-HSA-4086019) NCOR2-G97-SUMO1 [nucleoplasm] (R-HSA-3927883) DDX17-G97-SUMO1 [nucleoplasm] (R-HSA-3900210) PARK7-G97-SUMO1 [nucleoplasm] (R-HSA-4085344) K1033-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927910) K1056-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927954) K998-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927822) K1154-NRIP1-G97-SUMO1 [nucleoplasm] (R-HSA-4086067) K756-NRIP1-G97-SUMO1 [nucleoplasm] (R-HSA-4086034) DDX5-G97-SUMO1 [nucleoplasm] (R-HSA-3900212) CASP8AP2-G97-SUMO1 [nucleoplasm] (R-HSA-3927863) K1024-EP300-G97-SUMO1 [nucleoplasm] (R-HSA-3899298) K1020-EP300-G97-SUMO1 [nucleoplasm] (R-HSA-3899290) CTBP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730764) K231-SAFB-G97-SUMO1 [nucleoplasm] (R-HSA-4085364) K294-SAFB-G97-SUMO1 [nucleoplasm] (R-HSA-4085341) K624-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900128) K576-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900225) K499-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900219) K631-DAXX-G97-SUMO1 [nucleoplasm] (R-HSA-4086044) K630-DAXX-G97-SUMO1 [nucleoplasm] (R-HSA-4086012) SIN3A-G97-SUMO1 [nucleoplasm] (R-HSA-4086058) PPARGC1A-G97-SUMO1 [nucleoplasm] (R-HSA-3903014) HIPK2-G97-SUMO1 [nucleoplasm] (R-HSA-4090362) K774-NCOA1-G97-SUMO1 [nucleoplasm] (R-HSA-4085292) K732-NCOA1-G97-SUMO1 [nucleoplasm] (R-HSA-4085278) K538-MBD1-G97-SUMO1 [nucleoplasm] (R-HSA-4090416) K499-MBD1-G97-SUMO1 [nucleoplasm] (R-HSA-4090332) ZNF131-G97-SUMO1 [nucleoplasm] (R-HSA-3730875) K90-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755511) K689-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755446) K863-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755412) K298-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755505) p-S172-IKBKE-G97-SUMO1 [nucleoplasm] (R-HSA-4755408) K309-IKBKG-G97-SUMO1 [nucleoplasm] (R-HSA-4755404) K277-IKBKG-G97-SUMO1 [nucleoplasm] (R-HSA-4755531) NFKBIA-G97-SUMO1 [nucleoplasm] (R-HSA-4656987) AURKA-G97-SUMO1 [cytosol] (R-HSA-4655413) TOP2B-G97-SUMO1 [nucleoplasm] (R-HSA-4641311) TOP1-G97-SUMO1 [nucleoplasm] (R-HSA-4641306) TOP2A-G97-SUMO1 [nucleoplasm] (R-HSA-4641341) K254-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615853) K-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615836) K164-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615951) MDC1-G97-SUMO1 [nucleoplasm] (R-HSA-4570527) STAG2-G97-SUMO1 [nucleoplasm] (R-HSA-3826645) RAD21-G97-SUMO1 [nucleoplasm] (R-HSA-3826574) K411-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568857) K412-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568850) K414-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568900) XRCC4-G97-SUMO1 [nucleoplasm] (R-HSA-4568869) K160-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730884) K490-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730833) K65-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730879) K203-PARP1-G97-SUMO1 [nucleoplasm] (R-HSA-4551625) K486-PARP1-G97-SUMO1 [nucleoplasm] (R-HSA-4551748) K496-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568906) K898-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568893) K356-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568845) RNF168-SUMO1 [nucleoplasm] (R-HSA-4551631) XPC-G97-SUMO1 [nucleoplasm] (R-HSA-4570452) TDG-G97-SUMO1 [nucleoplasm] (R-HSA-4551682) SP100-G97-SUMO1 [nucleoplasm] (R-HSA-3730794) BRCA1-G97-SUMO1 [nucleoplasm] (R-HSA-3730735) RXRA-G97-SUMO1 [nucleoplasm] (R-HSA-4341090) NR5A2-G97-SUMO1 [nucleoplasm] (R-HSA-4755424) K386-AR-G97-SUMO1 [nucleoplasm] (R-HSA-4090321) K520-AR-G97-SUMO1 [nucleoplasm] (R-HSA-4090352) K293-NR3C1-G97-SUMO1 [nucleoplasm] (R-HSA-4341110) K277-NR3C1-G97-SUMO1 [nucleoplasm] (R-HSA-4341057) K389-THRA-G97-SUMO1 [nucleoplasm] (R-HSA-4719415) K283-THRA-G97-SUMO1 [nucleoplasm] (R-HSA-4719434) K399-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341020) K428-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341035) K494-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341093) K89-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341058) K119-NR5A1-G97-SUMO1 [nucleoplasm] (R-HSA-4546379) K194-NR5A1-G97-SUMO1 [nucleoplasm] (R-HSA-4546380) NR2C1-G97-SUMO1 [nucleoplasm] (R-HSA-4717492) K303-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090373) K266-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090359) K302-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090363) K299-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090349) K268-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090414) K531-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341021) K7-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341052) K388-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341056) K132-NR1H4-G97-SUMO1 [nucleoplasm] (R-HSA-9610527) NR1H4-G97-SUMO1 [nucleoplasm] (R-HSA-4755434) PPARG-G97-SUMO1 [nucleoplasm] (R-HSA-4717445) K395-PPARG-G97-SUMO1 [nucleoplasm] (R-HSA-4717446) PPARA-G97-SUMO1 [nucleoplasm] (R-HSA-4341069) K443-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719431) K146-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719410) K50-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719401) RORA-G97-SUMO1 [nucleoplasm] (R-HSA-4719426) HIC1-G97-SUMO1 [nucleoplasm] (R-HSA-4570544) TP53BP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730731) SP3-G97-SUMO1 [nucleoplasm] (R-HSA-3730646) K423-MITF-G97-SUMO1 [nucleoplasm] (R-HSA-3730755) K289-MITF-G97-SUMO1 [nucleoplasm] (R-HSA-3730738) K25-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968400) K150-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968382) K114-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968396) HNRNPC-G97-SUMO1 [nucleoplasm] (R-HSA-4570515) K497-NOP58-G97-SUMO1 [nucleoplasm] (R-HSA-4570504) K467-NOP58-G97-SUMO1 [nucleoplasm] (R-HSA-4570462) DNMT3B-G97-SUMO1 [nucleoplasm] (R-HSA-4655444) DNMT3A-G97-SUMO1 [nucleoplasm] (R-HSA-4655383) DNMT1-G97-SUMO1 [nucleoplasm] (R-HSA-4655358) K84-CBX5-G97-SUMO1 [nucleoplasm] (R-HSA-4615838) K-CBX5-G97-SUMO1 [nucleoplasm] (R-HSA-4615955) K476-HDAC1-G97-SUMO1 [nucleoplasm] (R-HSA-4615867) K444-HDAC1-G97-SUMO1 [nucleoplasm] (R-HSA-4616028) CBX4-G97-SUMO1 [nucleoplasm] (R-HSA-4551756) HDAC2-G97-SUMO1 [nucleoplasm] (R-HSA-4616032) SUZ12-G97-SUMO1 [nucleoplasm] (R-HSA-4615961) SATB1-G97-SUMO1 [nucleoplasm] (R-HSA-4615877) HDAC4-G97-SUMO1 [nucleoplasm] (R-HSA-4615956) K1971-CHD3-G97-SUMO1 [nucleoplasm] (R-HSA-8956370) HIST1H4-G97-SUMO1 [nucleoplasm] (R-HSA-4570549) BMI1-G97-SUMO1 [nucleoplasm] (R-HSA-4551654) TFAP2B-G97-SUMO1 [nucleoplasm] (R-HSA-3730839) TFAP2C-G97-SUMO1 [nucleoplasm] (R-HSA-3730823) TFAP2A-1-G97-SUMO1 [nucleoplasm] (R-HSA-3730825) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) RANGAP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730796) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) HERC2-SUMO1 [nucleoplasm] (R-HSA-4551761)	0.718	6
UniProt:P17275 JUNB	1	JUNB [nucleoplasm] (R-HSA-2186795)	0.693	3
UniProt:P17535 JUND	1	JUND [nucleoplasm] (R-HSA-9009924)	0.59	3
UniProt:Q9NR55 BATF3			0.59	2
UniProt:D3DQ93 VDAC1			0.576	3
UniProt:P19367 HK1	4	HK1 577-672del [cytosol] (R-HSA-5621873) HK1 T680S [cytosol] (R-HSA-5621880) HK1 L529S [cytosol] (R-HSA-5621861) HK1 [cytosol] (R-HSA-70395)	0.576	4
UniProt:Q99986 VRK1	2	VRK1 [nucleoplasm] (R-HSA-2528998) VRK1 [cytosol] (R-HSA-2995381)	0.571	5
UniProt:P0C746 HBZ			0.558	3
UniProt:Q96B26 EXOSC8	2	EXOSC8 [cytosol] (R-HSA-429912) EXOSC8 [nucleoplasm] (R-HSA-6791571)	0.556	3
UniProt:Q68G74 LHX8			0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:Q6FG41 Q6FG41			0.556	3
UniProt:P53539 FOSB	1	FOSB [nucleoplasm] (R-HSA-9009922)	0.556	3
UniProt:Q7L2Z9 CENPQ	2	CENPQ [cytosol] (R-HSA-375298) CENPQ [nucleoplasm] (R-HSA-606327)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:P78317 RNF4	2	RNF4 [cytosol] (R-HSA-975974) RNF4 [nucleoplasm] (R-HSA-5684076)	0.556	3
UniProt:Q6IQ16 SPOPL	1	SPOPL [nucleoplasm] (R-HSA-5635036)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:A4PIW0 A4PIW0			0.532	11
UniProt:Q8IUH5 ZDH17			0.508	3
UniProt:Q15532 SSXT			0.499	2
UniProt:O95644 NFATC1	3	p-S257-NFATC1 [cytosol] (R-HSA-2685618) p-S257-NFATC1 [nucleoplasm] (R-HSA-2025935) p-12S-NFATC1 [cytosol] (R-HSA-2025953)	0.499	2
UniProt:Q04724 TLE1	2	TLE1 [nucleoplasm] (R-HSA-212327) Ub-TLE1 [nucleoplasm] (R-HSA-3322369)	0.462	10

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