Reactome | p-T222,S272,T334-MAPKAPK2 [nucleoplasm]

p-T222,S272,T334-MAPKAPK2 [nucleoplasm]

Stable Identifier

R-HSA-450268

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S272,T222,T334-MAPKAPK2, Phospho-MAP kinase-activated protein kinase 2, MKK2_HUMAN, MAPKAPK2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P49137 MAPKAPK2

Gene Names

MAPKAPK2

Chain

chain:1-400

Reference Genes

COSMIC (genes):MAPKAPK2 MAPKAPK2

dbSNP Gene:9261 MAPKAPK2

ENSEMBL:ENSG00000162889 MAPKAPK2

Participates

as a member of

Active MAPKAP kinase [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MAPKAPK2 [cytosol]

p-T222,S272-MAPKAPK2 [nucleoplasm]

p-S272,T222,T334-MAPKAPK2 [cytosol]

MAPKAPK2 [nucleoplasm]

Inferred To

phospho-MAPKAPK2 [nucleoplasm] (Gallus gallus)

Homologues of p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Bos taurus)

phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Danio rerio)

phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)

phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Mus musculus)

phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Rattus norvegicus)

phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 222

Coordinate

222

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 272

Coordinate

272

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 334

Coordinate

334

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16539 MAPK14	7	MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.93	15
UniProt:Q15759 MAPK11	4	p-T180,Y182-MAPK11 [cytosol] (R-HSA-171009) MAPK11 [cytosol] (R-HSA-170989) MAPK11 [nucleoplasm] (R-HSA-203790) p-T180,Y182-MAPK11 [nucleoplasm] (R-HSA-198741)	0.643	4
UniProt:Q00613 HSF1	11	HSF1 [cytosol] (R-HSA-3371452) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) hC36,103-HSF1 [cytosol] (R-HSA-4793916) HSF1 [nucleoplasm] (R-HSA-5082385) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906)	0.602	5
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.571	3
UniProt:Q16644 MAPKAPK3	4	MAPKAPK3 [nucleoplasm] (R-HSA-450218) p-S,2T-MAPKAPK3 [nucleoplasm] (R-HSA-450359) p-S,2T-MAPKAPK3 [cytosol] (R-HSA-187723) MAPKAPK3 [cytosol] (R-HSA-187764)	0.527	3
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.488	2