Reactome | MAP2K7 [cytosol]

MAP2K7 [cytosol]

Stable Identifier

R-HSA-450276

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MAP2K7(2-419), MKK7, MAP kinase kinase 7

Icon

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
        
        MAP2K7 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated MAPK activation (Homo sapiens)
      - Phosphorylation of MEK7 by MEKK1 (Homo sapiens)
        
        MAP2K7 [cytosol] (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
        
        MAP2K7 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
        
        MAP2K7 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
        
        MAP2K7 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
        
        MAP2K7 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
        
        MAP2K7 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
        
        MAP2K7 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
        
        MAP2K7 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
        
        MAP2K7 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
        
        MAP2K7 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14733 MAP2K7

Gene Names

MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4

Chain

initiator methionine:, chain:2-419

Reference Genes

COSMIC (genes):MAP2K7 MAP2K7

dbSNP Gene:5609 MAP2K7

ENSEMBL:ENSG00000076984 MAP2K7

Participates

as an input of

as a member of

MAP2K7,MAP2K4 [cytosol] (Homo sapiens)

Other forms of this molecule

MAP2K7(?-419) [cytosol]

MAP2K7(2-?) [cytosol]

p-S271,T275-MAP2K7 [cytosol]

Inferred To

map2k7 [cytosol] (Danio rerio)

MAP2K7 [cytosol] (Canis familiaris)

MAP2K7 [cytosol] (Dictyostelium discoideum)

MAP2K7 [cytosol] (Mus musculus)

MAP2K7 [cytosol] (Rattus norvegicus)

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) p-T187-MAP3K7 [cytosol] (R-HSA-206014) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.674	3
IntAct:EBI-9998887 (DTP3)-TYR,ARG,PHE			0.672	7
UniProt:O75293 GA45B			0.645	8
UniProt:Q9UQF2 JIP1			0.623	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.483	4
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.462	3