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IRF7 [cytosol]
Stable Identifier
R-HSA-450281
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser for interactor UniProt:O94822
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Recruitment of IRF7 to TRAF6 (Homo sapiens)
IRF7 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92985 IRF7
Gene Names
IRF7
Chain
chain:1-503
Reference Genes
BioGPS Gene:3665 IRF7
COSMIC (genes):IRF7 IRF7
CTD Gene:3665 IRF7
dbSNP Gene:3665 IRF7
ENSEMBL:ENSG00000185507 IRF7
ENSEMBL_homo_sapiens_GENE:ENSG00000185507.21 IRF7
ENSEMBL_homo_sapiens_GENE:ENSG00000276561.4 IRF7
HGNC:6122 IRF7
Monarch:3665 IRF7
NCBI Gene:3665 IRF7
OMIM:605047 IRF7
UCSC:Q92985 IRF7
Reference Transcript
RefSeq:NM_001572.3 IRF7
RefSeq:NM_004031.2 IRF7
RefSeq:NM_004029.2 IRF7
RefSeq:XM_017017674.1 IRF7
RefSeq:XM_005252906.3 IRF7
Other Identifiers
11718916_a_at
16733995
208436_PM_s_at
208436_s_at
3358173
3358175
3358176
3358178
3358180
3358181
3358182
3358183
3358184
3358185
3358187
3358188
3358190
3358191
3358192
3358194
3358195
3358196
3358197
3358198
3358199
3358200
36412_s_at
3665
43350_f_at
74528_s_at
7945462
A_24_P378019
GE54698
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0002376
GO:0002753
GO:0002819
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005768
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006974
GO:0009615
GO:0010008
GO:0010468
GO:0012501
GO:0016064
GO:0019043
GO:0023052
GO:0030154
GO:0031410
GO:0032479
GO:0032481
GO:0032727
GO:0032728
GO:0034124
GO:0034127
GO:0039530
GO:0043226
GO:0045087
GO:0045655
GO:0045893
GO:0045944
GO:0048856
GO:0050776
GO:0051607
GO:0060337
GO:0060340
GO:0098542
GO:0140110
GO:1990837
GO:2000110
HMNXSV003008948
ILMN_1674646
ILMN_1798181
ILMN_2349061
PH_hs_0010006
TC11001241.hg
U53830_at
g4809285_3p_s_at
Participates
as an input of
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
Recruitment of IRF7 to TRAF6 (Homo sapiens)
as a component of
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
as a member of
IRF3,IRF7 [cytosol] (Homo sapiens)
IRF 1-9 [cytosol] (Homo sapiens)
Other forms of this molecule
K63polyUb-IRF7 [endosome membrane]
IRF7 [endosome membrane]
p-S477,S479-IRF7 [nucleoplasm]
p-S477,S479-IRF7 [cytosol]
Inferred To
irf7 [cytosol]
(Xenopus tropicalis)
IRF-3 [cytosol]
(Gallus gallus)
IRF7 [cytosol]
(Bos taurus)
IRF7 [cytosol]
(Sus scrofa)
Irf7 [cytosol]
(Mus musculus)
Irf7 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_004022.2
,
XP_016873163.1
,
XP_005252963.1
,
NP_004020.1
,
NP_001563.2
OpenTargets
ENSG00000185507
GeneCards
Q92985
HPA
ENSG00000185507-IRF7
Ensembl
ENSP00000488581
,
ENSP00000480358
,
ENST00000633943
,
ENST00000525445
,
ENST00000533182
,
ENST00000397566
,
ENSP00000380697
,
ENSP00000329411
,
ENST00000330243
,
ENST00000634105
,
ENSP00000488039
,
ENST00000612534
,
ENST00000348655
,
ENSP00000433903
,
ENST00000632827
,
ENSP00000331803
,
ENST00000633274
,
ENSG00000276561
,
ENSP00000488591
,
ENSP00000479615
,
ENSP00000488666
,
ENSG00000185507
,
ENSP00000434607
,
ENSP00000434009
,
ENST00000469048
,
ENST00000621391
PRO
Q92985
Pharos - Targets
Q92985
Orphanet
24630
HMDB Protein
HMDBP13795
PDB
2O61
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BVS5 TRMT61B
1
TRMT61B [mitochondrial matrix]
(R-HSA-6787512)
0.623
3
UniProt:P29128 ICP0
0.556
5
UniProt:Q9UHD2 TBK1
5
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
0.508
2
UniProt:F5HDE4 ORF45
0.508
3
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S582 ARAF [cytosol]
(R-HSA-5672646)
p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
(R-HSA-5672648)
p-S582 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S582 ARAF [cytosol]
(R-HSA-5672639)
0.499
2
UniProt:Q86UE8 TLK2
0.499
2
UniProt:O94822 LTN1
1
LTN1 [cytosol]
(R-HSA-5688967)
0.499
2
UniProt:Q9ULE6 PALD
0.499
2
UniProt:Q96A33 CCD47
0.499
2
UniProt:O00170 AIP
2
AIP [nucleoplasm]
(R-HSA-8937156)
AIP [cytosol]
(R-HSA-8936839)
0.499
2
UniProt:P51617 IRAK1
14
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
IRAK1 [cytosol]
(R-HSA-446639)
0.499
2
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