Reactome | p-S172-TBK1 [endosome membrane]

p-S172-TBK1 [endosome membrane]

Stable Identifier

R-HSA-450290

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

TANK-binding kinase 1(phosphorylated)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UHD2 TBK1

Gene Names

TBK1, NAK

Chain

chain:1-729

Reference Genes

BioGPS Gene:29110 TBK1

CTD Gene:29110 TBK1

dbSNP Gene:29110 TBK1

ENSEMBL:ENSG00000183735 TBK1

HGNC:11584 TBK1

KEGG Gene (Homo sapiens):29110 TBK1

Monarch:29110 TBK1

NCBI Gene:29110 TBK1

OMIM:604834 TBK1

UCSC:Q9UHD2 TBK1

Reference Transcript

Other Identifiers

0006380286

11717931_at

11717932_at

16753498

218520_at

29110

3419850

3419853

3419854

3419855

3419856

3419858

3419861

3419865

3419866

3419867

3419870

3419871

3419872

3419873

3419874

3419875

3419877

3419879

3419881

3419882

3419883

3419884

3419885

3419887

3419889

3419890

3419891

63819_at

7956795

A_14_P113016

A_23_P44768

GO:0000166

GO:0002218

GO:0002376

GO:0003674

GO:0003676

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0006464

GO:0006468

GO:0006914

GO:0006950

GO:0006954

GO:0007165

GO:0007249

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0009615

GO:0010008

GO:0010468

GO:0010629

GO:0016032

GO:0016239

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0019899

GO:0019903

GO:0031323

GO:0031410

GO:0032479

GO:0032480

GO:0032481

GO:0032606

GO:0032727

GO:0032728

GO:0033138

GO:0034641

GO:0035666

GO:0042802

GO:0043123

GO:0043167

GO:0043226

GO:0043231

GO:0044403

GO:0044565

GO:0045087

GO:0045359

GO:0045944

GO:0050830

GO:0051219

GO:0051607

GO:0060340

GO:0071345

GO:1901214

GO:1904417

ILMN_1739967

PH_hs_0025240

TC12000570.hg

g7019546_3p_at

Participant Of

hasMember

activated TBK1/IKK epsilon [endosome membrane]

Other forms of this molecule

p-TBK1 [cytosol]

pS-172,K48polyUb-TBK1 [cytosol]

p-S172-TBK1 [cytosol]

TBK1 [cytosol]

Inferred To

phospho-tbk1 [endosome membrane] (Danio rerio)

phospho-Tbk1 [endosome membrane] (Mus musculus)

phospho-Tbk1 [endosome membrane] (Rattus norvegicus)

phospho-TBK1 [endosome membrane] (Bos taurus)

phospho-TBK1 [endosome membrane] (Canis familiaris)

phospho-TBK1 [endosome membrane] (Gallus gallus)

phospho-TBK1 [endosome membrane] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 172

Coordinate

172

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_005268866.1, XP_005268867.1, NP_037386.1

ZINC - World Drugs

TBK1_HUMAN

OpenTargets

ENSG00000183735

ZINC - FDA approved

TBK1_HUMAN

ZINC - Substances

TBK1_HUMAN

ZINC target

Q9UHD2

ZINC - Biogenic

TBK1_HUMAN

PRO

Q9UHD2

PDB

5EP6, 5EOA, 6CQ4, 6BOD, 5W5V, 4IWP, 4IWQ, 6RST, 4IM0, 6CQ0, 6NT9, 4EFO, 6O8B, 6CQ5, 4EUT, 5EOF, 4IW0, 4IM2, 6BOE, 4IWO, 4IM3, 6RSR, 4EUU, 6BNY

ZINC - Investigational

TBK1_HUMAN

HPA

ENSG00000183735-TBK1

GeneCards

Q9UHD2

Ensembl

ENST00000331710, ENST00000650790, ENSP00000329967, ENSG00000183735, ENSP00000498995

ZINC - Predictions - Purchasable

TBK1_HUMAN

Orphanet

21615

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14653 IRF3	4	p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) IRF3 [cytosol] (R-HSA-166251)	0.92	10
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.916	13
UniProt:Q96CV9 OPTN	4	OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525)	0.863	15
UniProt:Q86WV6 STING1	5	K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) TMEM173 [endoplasmic reticulum membrane] (R-HSA-1834940) TMEM173 [plasma membrane] (R-HSA-6804815) TMEM173 [secretory granule membrane] (R-HSA-6804798)	0.862	8
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.822	6
UniProt:A7MCY6 TBKB1			0.816	8
UniProt:Q9H6S1 AZI2			0.758	6
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-NEMO [cytosol] (R-HSA-202530) IKBKG [cytosol] (R-HSA-168108)	0.702	4
UniProt:Q8IUC6 TICAM1	4	TICAM1 R141* [cytosol] (R-HSA-5602690) TICAM1 S186L [cytosol] (R-HSA-5607964) TICAM1 [endosome membrane] (R-HSA-450316) TICAM1 [cytosol] (R-HSA-166170)	0.688	3
UniProt:Q13137 CACO2			0.677	6
UniProt:Q14164 IKBKE	4	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [endosome membrane] (R-HSA-450278) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) SUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.669	5
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.623	5
UniProt:Q9UHD2 TBK1	5	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [endosome membrane] (R-HSA-450290)	0.609	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.589	3
UniProt:P42226 STAT6	6	p-S407,Y641-STAT6 [cytosol] (R-HSA-3249376) p-S407,Y641-STAT6 [nucleoplasm] (R-HSA-3261241) p-S407-STAT6 [cytosol] (R-HSA-3249369) p-Y641-STAT6 [nucleoplasm] (R-HSA-6786279) p-Y641-STAT6 [cytosol] (R-HSA-6786109) STAT6 [cytosol] (R-HSA-629625)	0.577	7
UniProt:P27958-PRO_0000037573			0.571	4
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.564	2
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.564	2
UniProt:I0DF37 I0DF37			0.556	3
UniProt:O75558 STX11			0.547	2
UniProt:Q05127 VP35			0.544	2
UniProt:O95801 TTC4			0.537	5
UniProt:I6W9F2 I6W9F2			0.537	6
UniProt:P27958-PRO_0000037572			0.524	2
UniProt:K7Y1A2 K7Y1A2			0.524	2
UniProt:Q92985 IRF7	5	IRF7 [endosome membrane] (R-HSA-450274) K63polyUb-IRF7 [endosome membrane] (R-HSA-975154) p-S477,S479-IRF7 [nucleoplasm] (R-HSA-450270) p-S477,S479-IRF7 [cytosol] (R-HSA-450318) IRF7 [cytosol] (R-HSA-450281)	0.508	2
UniProt:CYorf15B CY15B			0.499	2
UniProt:Q6DT37 MRCKG			0.499	2
UniProt:Q9Y6W8 ICOS			0.499	5
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) EIF2C2 [nucleoplasm] (R-HSA-5578701)	0.499	2
UniProt:Q9NVV4 PAPD1			0.499	2
UniProt:Q86YT6 MIB1	1	MIB1 [cytosol] (R-HSA-1472877)	0.499	2
UniProt:Q7Z3C6 ATG9A	1	ATG9A [phagophore assembly site membrane] (R-HSA-5671732)	0.499	2
UniProt:Q8BHN1 TXLNG			0.499	2
UniProt:Q96AX9 MIB2	1	MIB2 [cytosol] (R-HSA-1472879)	0.499	2
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.499	3
UniProt:O41932 O41932			0.488	4
UniProt:F1BA49 F1BA49			0.463	4
UniProt:Q96NL6 SCLT1	1	SCLT1 [cytosol] (R-HSA-5620935)	0.462	2

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