Reactome | p-S172-TBK1 [cytosol]

p-S172-TBK1 [cytosol]

Stable Identifier

R-HSA-450290

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TANK-binding kinase 1(phosphorylated)

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
    - TRAF3-dependent IRF activation pathway (Homo sapiens)
      - Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(IKK related kinases TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(IKK related kinases TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
      - Recruitment of IRF3,IRF7 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(IKK related kinases TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(IKK related kinases TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
      - TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(IKK related kinases TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
    - TRAF6 mediated IRF7 activation (Homo sapiens)
      - Phosphorylation and release of IRF7 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
      - Phosphorylation of TBK1/IKBKE (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
      - Recruitment of IRF7 to TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
        
        IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 (Homo sapiens)
        
        activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
        
        activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex (Homo sapiens)
        
        activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
        
        activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation (Homo sapiens)
        
        activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Homo sapiens)
        
        IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Homo sapiens)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Homo sapiens)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
        
        activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UHD2 TBK1

Gene Names

TBK1, NAK

Chain

chain:1-729

Reference Genes

BioGPS Gene:29110 TBK1

COSMIC (genes):TBK1 TBK1

CTD Gene:29110 TBK1

dbSNP Gene:29110 TBK1

ENSEMBL:ENSG00000183735 TBK1

HGNC:11584 TBK1

KEGG Gene (Homo sapiens):29110 TBK1

Monarch:29110 TBK1

NCBI Gene:29110 TBK1

OMIM:604834 TBK1

UCSC:Q9UHD2 TBK1

Reference Transcript

Other Identifiers

0006380286

11717931_at

11717932_at

16753498

218520_at

29110

3419850

3419853

3419854

3419855

3419856

3419858

3419861

3419865

3419866

3419867

3419870

3419871

3419872

3419873

3419874

3419875

3419877

3419879

3419881

3419882

3419883

3419884

3419885

3419887

3419889

3419890

3419891

63819_at

7956795

A_14_P113016

A_23_P44768

GO:0000166

GO:0002218

GO:0002376

GO:0003674

GO:0003676

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0006464

GO:0006468

GO:0006914

GO:0006950

GO:0006954

GO:0007165

GO:0007249

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0009615

GO:0010008

GO:0010468

GO:0010629

GO:0016032

GO:0016239

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0019899

GO:0019903

GO:0031323

GO:0031410

GO:0032479

GO:0032480

GO:0032481

GO:0032606

GO:0032727

GO:0032728

GO:0033138

GO:0034641

GO:0035666

GO:0042802

GO:0043123

GO:0043167

GO:0043226

GO:0043231

GO:0044403

GO:0044565

GO:0045087

GO:0045944

GO:0050830

GO:0051219

GO:0051607

GO:0060340

GO:0071345

GO:0106310

GO:0106311

GO:1901214

GO:1904417

HMNXSV003037647

ILMN_1739967

PH_hs_0025240

TC12000570.hg

g7019546_3p_at

Participates

as a member of

activated TBK1/IKK epsilon [cytosol] (Homo sapiens)

Other forms of this molecule

pS-172,K48polyUb-TBK1 [cytosol]

p-S172-TBK1 [cytosol]

p-TBK1 [cytosol]

TBK1 [cytosol]

Inferred To

phospho-TBK1 [cytosol] (Gallus gallus)

phospho-TBK1 [cytosol] (Sus scrofa)

p-S172-Tbk1 [cytosol] (Mus musculus)

Modified Residues

Name

O-phospho-L-serine at 172

Coordinate

172

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_005268867.1, XP_005268866.1, NP_037386.1

ZINC - World Drugs

TBK1_HUMAN

OpenTargets

ENSG00000183735

ZINC - FDA approved

TBK1_HUMAN

ZINC - Substances

TBK1_HUMAN

ZINC - Biogenic

TBK1_HUMAN

ZINC target

Q9UHD2

PRO

Q9UHD2

PDB

6CQ4, 6BOE, 6RSR, 6CQ5, 5EOF, 4EUU, 6RST, 4IWO, 5W5V, 4EUT, 6RSU, 4IWP, 5EP6, 4IM0, 4IWQ, 6O8B, 4IM2, 4IW0, 6BNY, 4EFO, 4IM3, 6CQ0, 6NT9, 5EOA, 6BOD

ZINC - Investigational

TBK1_HUMAN

GeneCards

Q9UHD2

HPA

ENSG00000183735-TBK1

Ensembl

ENSP00000329967, ENSG00000183735, ENST00000650790, ENSP00000498995, ENST00000331710

Orphanet

21615

ZINC - Predictions - Purchasable

TBK1_HUMAN

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14653 IRF3	4	IRF3 [cytosol] (R-HSA-166251) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-4S,T404-IRF3 [cytosol] (R-HSA-166258)	0.92	10
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.916	13
UniProt:Q86WV6 STING1	5	K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) STING [endoplasmic reticulum membrane] (R-HSA-1834940) TMEM173 [plasma membrane] (R-HSA-6804815) TMEM173 [secretory granule membrane] (R-HSA-6804798)	0.899	9
UniProt:Q96CV9 OPTN	4	OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525)	0.863	15
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.822	6
UniProt:A7MCY6 TBKB1			0.816	8
UniProt:Q9H6S1 AZI2			0.758	6
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-NEMO [cytosol] (R-HSA-202530) IKBKG [cytosol] (R-HSA-168108)	0.702	4
UniProt:Q8IUC6 TICAM1	4	TICAM1 R141* [cytosol] (R-HSA-5602690) TICAM1 S186L [cytosol] (R-HSA-5607964) TICAM1 [endosome membrane] (R-HSA-450316) TICAM1 [cytosol] (R-HSA-166170)	0.688	3
UniProt:Q13137 CACO2			0.677	6
UniProt:P0DTD1-PRO_0000449630 REP			0.669	3
UniProt:Q14164 IKBKE	4	p-S172-IKBKE [cytosol] (R-HSA-450278) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) SUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.669	5
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.623	5
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) p-S172-TBK1 [cytosol] (R-HSA-450290) TBK1 [cytosol] (R-HSA-166267)	0.609	2
UniProt:Q60803	3	Traf3 [cytosol] (R-MMU-914241) Traf3 [cytosol] (R-MMU-5668444) Traf3 [cytosol] (R-MMU-936402)	0.589	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.589	3
UniProt:P59596 M	8	N-glycan M [endocytic vesicle membrane] (R-COV-9686698) M [endocytic vesicle membrane] (R-COV-9686687) N-glycan M [endoplasmic reticulum membrane] (R-COV-9683588) nascent M [endoplasmic reticulum lumen] (R-COV-9683586) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684206) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684213) M [virion membrane] (R-COV-9678151) N-glycan M [virion membrane] (R-COV-9685474)	0.589	4
UniProt:P42226 STAT6	6	p-S407,Y641-STAT6 [cytosol] (R-HSA-3249376) p-S407,Y641-STAT6 [nucleoplasm] (R-HSA-3261241) p-S407-STAT6 [cytosol] (R-HSA-3249369) STAT6 [cytosol] (R-HSA-629625) p-Y641-STAT6 [nucleoplasm] (R-HSA-6786279) p-Y641-STAT6 [cytosol] (R-HSA-6786109)	0.577	7
UniProt:P27958-PRO_0000037573			0.571	4
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.564	2
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.564	2
UniProt:I0DF37 I0DF37			0.556	3
UniProt:O75558 STX11			0.547	2
UniProt:Q05127 VP35			0.544	2
UniProt:O95801 TTC4			0.537	5
UniProt:I6W9F2 I6W9F2			0.537	6
UniProt:P27958-PRO_0000037572			0.524	2
UniProt:K7Y1A2 K7Y1A2			0.524	2
UniProt:Q92985 IRF7	5	IRF7 [endosome membrane] (R-HSA-450274) K63polyUb-IRF7 [endosome membrane] (R-HSA-975154) IRF7 [cytosol] (R-HSA-450281) p-S477,S479-IRF7 [nucleoplasm] (R-HSA-450270) p-S477,S479-IRF7 [cytosol] (R-HSA-450318)	0.508	2
UniProt:CYorf15B CY15B			0.499	2
UniProt:Q6DT37 MRCKG			0.499	2
UniProt:Q9Y6W8 ICOS			0.499	5
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) EIF2C2 [nucleoplasm] (R-HSA-5578701)	0.499	2
UniProt:Q9NVV4 PAPD1			0.499	2
UniProt:Q86YT6 MIB1	1	MIB1 [cytosol] (R-HSA-1472877)	0.499	2
UniProt:Q7Z3C6 ATG9A	1	ATG9A [phagophore assembly site membrane] (R-HSA-5671732)	0.499	2
UniProt:Q8BHN1 TXLNG			0.499	2
UniProt:Q96AX9 MIB2	1	MIB2 [cytosol] (R-HSA-1472879)	0.499	2
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.499	3
UniProt:O41932 O41932			0.488	4
UniProt:F1BA49 F1BA49			0.463	4
UniProt:P0DTD2 9b	1	9b [cytosol] (R-COV-9694649)	0.463	2