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p-S172-TBK1 [cytosol]
Stable Identifier
R-HSA-450290
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TANK-binding kinase 1(phosphorylated)
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
p-S172-TBK1 [cytosol] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
p-S172-TBK1 [cytosol] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
p-S172-TBK1 [cytosol] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
p-S172-TBK1 [cytosol] (Homo sapiens)
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
p-S172-TBK1 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Homo sapiens)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
p-S172-TBK1 [cytosol] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
p-S172-TBK1 [cytosol] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
p-S172-TBK1 [cytosol] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
p-S172-TBK1 [cytosol] (Homo sapiens)
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
activated TBK1/IKK epsilon [cytosol] (Homo sapiens)
p-S172-TBK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UHD2 TBK1
Gene Names
TBK1, NAK
Chain
chain:1-729
Reference Genes
BioGPS Gene:29110 TBK1
COSMIC (genes):TBK1 TBK1
CTD Gene:29110 TBK1
dbSNP Gene:29110 TBK1
ENSEMBL:ENSG00000183735 TBK1
HGNC:11584 TBK1
KEGG Gene (Homo sapiens):29110 TBK1
Monarch:29110 TBK1
NCBI Gene:29110 TBK1
OMIM:604834 TBK1
UCSC:Q9UHD2 TBK1
Reference Transcript
RefSeq:XM_005268810.1 TBK1
RefSeq:XM_005268809.1 TBK1
RefSeq:NM_013254.3 TBK1
Other Identifiers
0006380286
11717931_at
11717932_at
16753498
218520_at
29110
3419850
3419853
3419854
3419855
3419856
3419858
3419861
3419865
3419866
3419867
3419870
3419871
3419872
3419873
3419874
3419875
3419877
3419879
3419881
3419882
3419883
3419884
3419885
3419887
3419889
3419890
3419891
63819_at
7956795
A_14_P113016
A_23_P44768
GO:0000166
GO:0002218
GO:0002376
GO:0003674
GO:0003676
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0006464
GO:0006468
GO:0006914
GO:0006950
GO:0006954
GO:0007165
GO:0007249
GO:0008150
GO:0008219
GO:0008283
GO:0009056
GO:0009058
GO:0009615
GO:0010008
GO:0010468
GO:0010629
GO:0016032
GO:0016239
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019899
GO:0019903
GO:0031323
GO:0031410
GO:0032479
GO:0032480
GO:0032481
GO:0032606
GO:0032727
GO:0032728
GO:0033138
GO:0034641
GO:0035666
GO:0042802
GO:0043123
GO:0043167
GO:0043226
GO:0043231
GO:0044403
GO:0044565
GO:0045087
GO:0045944
GO:0050830
GO:0051219
GO:0051607
GO:0060340
GO:0071345
GO:1901214
GO:1904417
ILMN_1739967
PH_hs_0025240
TC12000570.hg
g7019546_3p_at
Participant Of
hasMember
activated TBK1/IKK epsilon [cytosol]
Other forms of this molecule
pS-172,K48polyUb-TBK1 [cytosol]
p-S172-TBK1 [cytosol]
p-TBK1 [cytosol]
TBK1 [cytosol]
Inferred To
phospho-TBK1 [cytosol] (Canis familiaris)
phospho-TBK1 [cytosol] (Gallus gallus)
phospho-TBK1 [cytosol] (Sus scrofa)
p-S172-Tbk1 [cytosol] (Mus musculus)
phospho-tbk1 [cytosol] (Danio rerio)
phospho-Tbk1 [cytosol] (Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 172
Coordinate
172
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_037386.1
,
XP_005268867.1
,
XP_005268866.1
ZINC - World Drugs
TBK1_HUMAN
OpenTargets
ENSG00000183735
ZINC - FDA approved
TBK1_HUMAN
ZINC - Substances
TBK1_HUMAN
ZINC target
Q9UHD2
ZINC - Biogenic
TBK1_HUMAN
PRO
Q9UHD2
PDB
6BNY
,
6CQ5
,
6NT9
,
5EOF
,
4IM3
,
4IM2
,
6O8B
,
6CQ4
,
5EOA
,
4EUT
,
6RSU
,
4IWO
,
6CQ0
,
4IWQ
,
5W5V
,
4EFO
,
5EP6
,
6BOE
,
4EUU
,
6RST
,
4IWP
,
4IW0
,
4IM0
,
6RSR
,
6BOD
ZINC - Investigational
TBK1_HUMAN
HPA
ENSG00000183735-TBK1
GeneCards
Q9UHD2
Ensembl
ENST00000331710
,
ENSP00000329967
,
ENSG00000183735
,
ENSP00000498995
,
ENST00000650790
Orphanet
21615
ZINC - Predictions - Purchasable
TBK1_HUMAN
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14653 IRF3
4
p-4S,T404-IRF3 [nucleoplasm]
(R-HSA-177654)
p-5S,T404-IRF3 [nucleoplasm]
(R-HSA-936418)
p-4S,T404-IRF3 [cytosol]
(R-HSA-166258)
IRF3 [cytosol]
(R-HSA-166251)
0.92
10
UniProt:Q92844 TANK
2
TANK [cytosol]
(R-HSA-933407)
K63polyUb-TANK [cytosol]
(R-HSA-5362480)
0.916
13
UniProt:Q86WV6 STING1
5
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
TMEM173 [endoplasmic reticulum membrane]
(R-HSA-1834940)
0.899
9
UniProt:Q96CV9 OPTN
4
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
0.863
15
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.822
6
UniProt:A7MCY6 TBKB1
0.816
8
UniProt:Q9H6S1 AZI2
0.758
6
UniProt:Q9Y6K9 IKBKG
12
IKBKG [nucleoplasm]
(R-HSA-4755413)
SUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
IKBKG [cytosol]
(R-HSA-168108)
0.702
4
UniProt:Q8IUC6 TICAM1
4
TICAM1 R141* [cytosol]
(R-HSA-5602690)
TICAM1 S186L [cytosol]
(R-HSA-5607964)
TICAM1 [endosome membrane]
(R-HSA-450316)
TICAM1 [cytosol]
(R-HSA-166170)
0.688
3
UniProt:Q13137 CACO2
0.677
6
UniProt:Q14164 IKBKE
4
p-S172-IKBKE [cytosol]
(R-HSA-450278)
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
SUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
0.669
5
UniProt:P40222 TXLNA
1
TXLNA [cytosol]
(R-HSA-449124)
0.623
5
UniProt:Q9UHD2 TBK1
5
p-S172-TBK1 [cytosol]
(R-HSA-168379)
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-S172-TBK1 [cytosol]
(R-HSA-450290)
p-TBK1 [cytosol]
(R-HSA-9008705)
TBK1 [cytosol]
(R-HSA-166267)
0.609
2
UniProt:Q60803
3
Traf3 [cytosol]
(R-MMU-914241)
Traf3 [cytosol]
(R-MMU-5668444)
Traf3 [cytosol]
(R-MMU-936402)
0.589
2
UniProt:P59596 M
8
N-glycan M [endocytic vesicle membrane]
(R-COV-9686698)
M [endocytic vesicle membrane]
(R-COV-9686687)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9683588)
nascent M [endoplasmic reticulum lumen]
(R-COV-9683586)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9684206)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9684213)
M [virion membrane]
(R-COV-9678151)
N-glycan M [virion membrane]
(R-COV-9685474)
0.589
4
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.589
3
UniProt:P42226 STAT6
6
p-S407,Y641-STAT6 [nucleoplasm]
(R-HSA-3261241)
p-S407-STAT6 [cytosol]
(R-HSA-3249369)
p-S407,Y641-STAT6 [cytosol]
(R-HSA-3249376)
STAT6 [cytosol]
(R-HSA-629625)
p-Y641-STAT6 [nucleoplasm]
(R-HSA-6786279)
p-Y641-STAT6 [cytosol]
(R-HSA-6786109)
0.577
7
UniProt:P27958-PRO_0000037573
0.571
4
UniProt:Q7Z434 MAVS
2
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
0.564
2
UniProt:P04406 GAPDH
1
GAPDH [cytosol]
(R-HSA-70428)
0.564
2
UniProt:I0DF37 I0DF37
0.556
3
UniProt:O75558 STX11
0.547
2
UniProt:Q05127 VP35
0.544
2
UniProt:O95801 TTC4
0.537
5
UniProt:I6W9F2 I6W9F2
0.537
6
UniProt:P0DTD1-PRO_0000449630 REP
0.527
2
UniProt:P27958-PRO_0000037572
0.524
2
UniProt:K7Y1A2 K7Y1A2
0.524
2
UniProt:Q92985 IRF7
5
IRF7 [endosome membrane]
(R-HSA-450274)
K63polyUb-IRF7 [endosome membrane]
(R-HSA-975154)
p-S477,S479-IRF7 [nucleoplasm]
(R-HSA-450270)
p-S477,S479-IRF7 [cytosol]
(R-HSA-450318)
IRF7 [cytosol]
(R-HSA-450281)
0.508
2
UniProt:CYorf15B CY15B
0.499
2
UniProt:O14730 RIOK3
1
RIOK3 [cytosol]
(R-HSA-6791522)
0.499
3
UniProt:Q6DT37 MRCKG
0.499
2
UniProt:Q9Y6W8 ICOS
0.499
5
UniProt:Q9UKV8 AGO2
2
AGO2 [cytosol]
(R-HSA-209723)
EIF2C2 [nucleoplasm]
(R-HSA-5578701)
0.499
2
UniProt:Q9NVV4 PAPD1
0.499
2
UniProt:Q86YT6 MIB1
1
MIB1 [cytosol]
(R-HSA-1472877)
0.499
2
UniProt:Q7Z3C6 ATG9A
1
ATG9A [phagophore assembly site membrane]
(R-HSA-5671732)
0.499
2
UniProt:Q8BHN1 TXLNG
0.499
2
UniProt:Q96AX9 MIB2
1
MIB2 [cytosol]
(R-HSA-1472879)
0.499
2
UniProt:O41932 O41932
0.488
4
UniProt:F1BA49 F1BA49
0.463
4
UniProt:P0DTD2 9b
1
9b [cytosol]
(R-COV-9694649)
0.463
2
UniProt:Q96NL6 SCLT1
1
SCLT1 [cytosol]
(R-HSA-5620935)
0.462
2
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