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2xp-S477,S479-IRF7 [nucleoplasm]
Stable Identifier
R-HSA-450306
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Dimerized phospho-IRF3, IRF7 is transported to the nucleus (Homo sapiens)
phosphorylated IRF3 and/or IRF7 dimer [nucleoplasm] (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Homo sapiens)
p-IRF7:p-IRF7 translocates to the nucleus (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF3-dependent IRF activation pathway (Homo sapiens)
Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 (Homo sapiens)
VAF/pIRF7:CBP/p300 [nucleoplasm] (Homo sapiens)
CBP/p300:pIRF7:pIRF7 [nucleoplasm] (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
VAF/pIRF7:CBP/p300 bound to type I IFN gene promoter [nucleoplasm] (Homo sapiens)
VAF/pIRF7:CBP/p300 [nucleoplasm] (Homo sapiens)
CBP/p300:pIRF7:pIRF7 [nucleoplasm] (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes (Homo sapiens)
VAF/pIRF7:CBP/p300 [nucleoplasm] (Homo sapiens)
CBP/p300:pIRF7:pIRF7 [nucleoplasm] (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
VAF/pIRF7:CBP/p300 bound to type I IFN gene promoter [nucleoplasm] (Homo sapiens)
VAF/pIRF7:CBP/p300 [nucleoplasm] (Homo sapiens)
CBP/p300:pIRF7:pIRF7 [nucleoplasm] (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
p-IRF7 dimer interacts with coactivator CBP/p300 (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
CBP/p300:pIRF7:pIRF7 [nucleoplasm] (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
phosphorylated IRF3 and/or IRF7 dimer [nucleoplasm] (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
phosphorylated IRF3 and/or IRF7 dimer [nucleoplasm] (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)
2xp-S477,S479-IRF7 [nucleoplasm] (Homo sapiens)
Participants
components
x 2
p-S477,S479-IRF7 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
p-IRF7:p-IRF7 translocates to the nucleus (Homo sapiens)
Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)
Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Homo sapiens)
as an input of
p-IRF7 dimer interacts with coactivator CBP/p300 (Homo sapiens)
as a component of
CBP/p300:pIRF7:pIRF7 [nucleoplasm] (Homo sapiens)
as a member of
phosphorylated IRF3 and/or IRF7 dimer [nucleoplasm] (Homo sapiens)
Inferred To
2xp-S477,S479-IRF7 [nucleoplasm]
(Bos taurus)
2xp-S477,S479-IRF7 [nucleoplasm]
(Gallus gallus)
2xp-S477,S479-IRF7 [nucleoplasm]
(Mus musculus)
2xp-S477,S479-IRF7 [nucleoplasm]
(Rattus norvegicus)
2xp-S477,S479-IRF7 [nucleoplasm]
(Sus scrofa)
2xp-S477,S479-IRF7 [nucleoplasm]
(Xenopus tropicalis)
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