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MAP3K7 [endosome membrane]
Stable Identifier
R-HSA-450315
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
TAK1, Mitogen-activated protein kinase kinase kinase 7
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1,TRAF6-dependent induction of TAK1 complex (Homo sapiens)
Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)
viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] (Homo sapiens)
MAP3K7 [endosome membrane] (Homo sapiens)
Activation of recruited TAK1 within the activated TLR3 complex (Homo sapiens)
MAP3K7 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] (Homo sapiens)
MAP3K7 [endosome membrane] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Homo sapiens)
TAK1 complex [endosome membrane] (Homo sapiens)
MAP3K7 [endosome membrane] (Homo sapiens)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Homo sapiens)
TAK1 complex [endosome membrane] (Homo sapiens)
MAP3K7 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Homo sapiens)
TAK1 complex [endosome membrane] (Homo sapiens)
MAP3K7 [endosome membrane] (Homo sapiens)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Homo sapiens)
TAK1 complex [endosome membrane] (Homo sapiens)
MAP3K7 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43318 MAP3K7
Gene Names
MAP3K7, TAK1
Chain
chain:1-606
Reference Genes
BioGPS Gene:6885 MAP3K7
COSMIC (genes):MAP3K7 MAP3K7
CTD Gene:6885 MAP3K7
dbSNP Gene:6885 MAP3K7
ENSEMBL:ENSG00000135341 MAP3K7
ENSEMBL_homo_sapiens_GENE:ENSG00000135341.19 MAP3K7
HGNC:6859 MAP3K7
KEGG Gene (Homo sapiens):6885 MAP3K7
Monarch:6885 MAP3K7
NCBI Gene:6885 MAP3K7
OMIM:602614 MAP3K7
UCSC:O43318 MAP3K7
Reference Transcript
RefSeq:NM_145332.2 MAP3K7
RefSeq:NM_145333.2 MAP3K7
RefSeq:NM_003188.3 MAP3K7
RefSeq:NM_145331.2 MAP3K7
Other Identifiers
11736829_a_at
11736830_s_at
11741475_a_at
11741476_x_at
11742225_a_at
11743919_a_at
11750993_x_at
17021754
206853_PM_s_at
206853_s_at
206854_PM_s_at
206854_s_at
211536_PM_x_at
211536_x_at
211537_PM_x_at
211537_x_at
2964772
2964773
2964774
2964775
2964776
2964777
2964778
2964779
2964780
2964782
2964783
2964784
2964786
2964790
2964799
2964802
2964804
2964805
2964807
2964808
2964809
2964811
2964812
2964813
2964814
2964819
2964820
2964821
2964822
36905_at
53270_s_at
6885
8128260
86022_at
A_23_P500773
GE56544
GE80617
GO:0000165
GO:0000166
GO:0000287
GO:0001223
GO:0001666
GO:0002223
GO:0002376
GO:0002726
GO:0002753
GO:0002755
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0004709
GO:0005114
GO:0005515
GO:0005524
GO:0005634
GO:0005694
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0006325
GO:0006338
GO:0006468
GO:0006914
GO:0006915
GO:0006954
GO:0006955
GO:0007165
GO:0007179
GO:0007249
GO:0007250
GO:0007252
GO:0007254
GO:0008349
GO:0010008
GO:0010508
GO:0010629
GO:0012501
GO:0016020
GO:0016239
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030971
GO:0031410
GO:0031625
GO:0032743
GO:0034138
GO:0034142
GO:0035173
GO:0035666
GO:0036211
GO:0038066
GO:0038095
GO:0038172
GO:0038173
GO:0042742
GO:0042802
GO:0043123
GO:0043226
GO:0043276
GO:0043410
GO:0043507
GO:0045787
GO:0045793
GO:0046872
GO:0048870
GO:0050852
GO:0051403
GO:0070423
GO:0070498
GO:0071356
GO:0071456
GO:0071560
GO:0097110
GO:0098542
GO:0106310
GO:0120283
GO:0140096
GO:0140297
GO:0140672
GO:1901224
GO:1904385
GO:1904707
GO:1904754
GO:1990450
GO:1990776
HMNXSV003034824
Hs.7510.0.S2_3p_a_at
ILMN_1810176
ILMN_2379326
PH_hs_0028131
PH_hs_0035759
TC06001948.hg
g4507360_3p_a_at
g8978251_3p_a_at
Participates
as a component of
TAK1 complex [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] (Homo sapiens)
Other forms of this molecule
PolyUb-MAP3K7 [cytosol]
MAP3K7 [plasma membrane]
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
K63polyUb-34,158-TAK1 [cytosol]
p-MAP3K7 [cytosol]
p-T187-MAP3K7 [cytosol]
p-T184,T187-MAP3K7 [endosome membrane]
MAP3K7 [cytosol]
p-T184,T187-MAP3K7 [cytosol]
Inferred To
MAP3K7 [endosome membrane]
(Bos taurus)
MAP3K7 [endosome membrane]
(Canis familiaris)
MAP3K7 [endosome membrane]
(Gallus gallus)
MAP3K7 [endosome membrane]
(Mus musculus)
MAP3K7 [endosome membrane]
(Rattus norvegicus)
MAP3K7 [endosome membrane]
(Sus scrofa)
MAP3K7 [endosome membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003179.1
,
NP_663305.1
,
NP_663304.1
,
NP_663306.1
ZINC - World Drugs
M3K7_HUMAN
Guide to Pharmacology - Targets
2082
OpenTargets
ENSG00000135341
ZINC - FDA approved
M3K7_HUMAN
ZINC - Substances
M3K7_HUMAN
ZINC - Biogenic
M3K7_HUMAN
ZINC target
O43318
PRO
O43318
PDB
5JGA
,
5GJF
,
5JK3
,
4L52
,
5JH6
,
5JGB
,
5GJG
,
5J9L
,
7NTH
,
4L3P
,
4GS6
,
2YIY
,
5E7R
,
5J7S
,
5GJD
,
5V5N
,
8GW3
,
5J8I
,
5JGD
,
2EVA
,
4L53
,
4O91
,
7NTI
ZINC - Investigational
M3K7_HUMAN
GeneCards
O43318
HPA
ENSG00000135341-MAP3K7
Ensembl
ENST00000369325
,
ENST00000369332
,
ENSP00000358335
,
ENSP00000358333
,
ENSG00000135341
,
ENSP00000358331
,
ENSP00000515074
,
ENST00000369327
,
ENST00000369329
,
ENST00000700580
,
ENSP00000358338
Pharos - Targets
O43318
ZINC - Predictions - Purchasable
M3K7_HUMAN
Orphanet
24131
HMDB Protein
HMDBP01334
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NYJ8 TAB2
4
TAB2 [cytosol]
(R-HSA-168117)
TAB2 [endosome membrane]
(R-HSA-450279)
TAB2 [plasma membrane]
(R-HSA-168116)
TAB2 [nucleoplasm]
(R-HSA-1253323)
0.91
8
UniProt:Q15750 TAB1
6
TAB1(445-504) [cytosol]
(R-HSA-9729691)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1 [cytosol]
(R-HSA-167923)
0.899
10
UniProt:Q8N5C8 TAB3
3
TAB3 [plasma membrane]
(R-HSA-446879)
TAB3 [endosome membrane]
(R-HSA-450247)
TAB3 [cytosol]
(R-HSA-450264)
0.773
5
UniProt:Q9UQF2 JIP1
0.723
11
UniProt:O14733 MAP2K7
4
MAP2K7(?-419) [cytosol]
(R-HSA-5211401)
MAP2K7(2-?) [cytosol]
(R-HSA-5211389)
MAP2K7 [cytosol]
(R-HSA-450276)
p-S271,T275-MAP2K7 [cytosol]
(R-HSA-450353)
0.674
3
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.669
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.669
4
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.657
6
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.656
4
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.65
3
UniProt:B5Z6S0 B5Z6S0
0.602
4
UniProt:O00743 PPP6C
2
PPP6C [cytosol]
(R-HSA-5685719)
PPP6C [nucleoplasm]
(R-HSA-9686576)
0.602
4
UniProt:Q9UBE8 NLK
3
NLK [cytosol]
(R-HSA-4411330)
p-T298-NLK [cytosol]
(R-HSA-4411398)
p-T298-NLK [nucleoplasm]
(R-HSA-4411376)
0.569
3
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.558
4
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.556
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
3
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.527
2
UniProt:Q9UKE5 TNIK
1
TNIK [cytosol]
(R-HSA-3214889)
0.499
3
UniProt:P15311 EZR
3
p-Y146,Y354-EZR [cytosol]
(R-HSA-374572)
p-T567-EZR [cytosol]
(R-HSA-374559)
EZR [cytosol]
(R-HSA-9020826)
0.483
2
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