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TICAM1 [endosome membrane]
Stable Identifier
R-HSA-450316
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
TRIF
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
TRAF3 deficiency - HSE (Homo sapiens)
Defective TRAF3 does not transmit the signal (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
RIP1 facilitates IKK complex phosphorylation (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
SARM binds viral dsRNA:TLR3:TICAM1 (Homo sapiens)
SARM:TICAM1:viral dsRNA:TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TICAM1, RIP1-mediated IKK complex recruitment (Homo sapiens)
IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex (Homo sapiens)
activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-RIP1:CHUK:IKBKB:IKBKG [endosome membrane] (Homo sapiens)
activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
Viral dsRNA:TLR3:TRIF complex recruits RIP1 (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TICAM1,TRAF6-dependent induction of TAK1 complex (Homo sapiens)
Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
Activation of recruited TAK1 within the activated TLR3 complex (Homo sapiens)
viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
Phosphorylated TAK1 dissociates from the TLR3 receptor complex (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
Auto-ubiquitination of TRAF3 within activated TLR3 complex (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TRAF3 binds to TRIF:activated TLR3 complex (Homo sapiens)
TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TLR3-mediated TICAM1-dependent programmed cell death (Homo sapiens)
Caspase-8 processing within TLR3 complex (Homo sapiens)
activated TLR3:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis (Homo sapiens)
RIP3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1:RIPK3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TICAM1:activated TLR3 complexes [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
TLR3-induced ripoptosome assembly (Homo sapiens)
activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
Viral dsRNA:TLR3 recruits TRIF (TICAM1) (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
TICAM1 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IUC6 TICAM1
Gene Names
TICAM1, PRVTIRB, TRIF
Chain
chain:1-712
Reference Genes
BioGPS Gene:148022 TICAM1
COSMIC (genes):TICAM1 TICAM1
CTD Gene:148022 TICAM1
dbSNP Gene:148022 TICAM1
ENSEMBL:ENSG00000127666.11 TICAM1
HGNC:18348 TICAM1
KEGG Gene (Homo sapiens):148022 TICAM1
Monarch:148022 TICAM1
NCBI Gene:148022 TICAM1
OMIM:607601 TICAM1
UCSC:Q8IUC6 TICAM1
Reference Transcript
RefSeq:NM_182919.3 TICAM1
Other Identifiers
0003870093
0007040520
11719258_at
148022
16867409
213191_PM_at
213191_at
35230_at
3846983
3846984
3846985
3846986
3846987
3846988
3846989
3846990
3846991
3846992
3846993
3846994
3846995
3846996
3846997
3846998
3846999
3847000
8032899
A_23_P376096
A_23_P90311
GE54626
GE803521
GO:0002281
GO:0002376
GO:0002735
GO:0002756
GO:0005515
GO:0005622
GO:0005737
GO:0005739
GO:0005768
GO:0005773
GO:0005776
GO:0005829
GO:0006351
GO:0006355
GO:0006809
GO:0006914
GO:0006915
GO:0006954
GO:0007165
GO:0007249
GO:0010008
GO:0010508
GO:0010628
GO:0012501
GO:0019901
GO:0023052
GO:0030890
GO:0031398
GO:0031410
GO:0031663
GO:0032092
GO:0032481
GO:0032496
GO:0032722
GO:0032728
GO:0032755
GO:0032760
GO:0032816
GO:0032991
GO:0035666
GO:0036211
GO:0042100
GO:0042113
GO:0043123
GO:0043226
GO:0043254
GO:0043330
GO:0045087
GO:0045429
GO:0050871
GO:0050896
GO:0051092
GO:0051607
GO:0060907
GO:0065003
GO:0071222
GO:0097190
GO:0097342
GO:0098542
GO:0140052
GO:1900017
HMNXSV003006219
Hs.29344.0.S1_3p_at
ILMN_1724863
ILMN_1815079
PH_hs_0002548
RNA95678|RNS_760_128
TC19001071.hg
Participates
as a component of
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
Other forms of this molecule
TICAM1 S186L [cytosol]
TICAM1 R141* [cytosol]
TICAM1 [cytosol]
Cross References
RefSeq
NP_891549.1
OpenTargets
ENSG00000127666
GeneCards
Q8IUC6
HPA
ENSG00000127666-TICAM1
Ensembl
ENST00000248244
,
ENSG00000127666
,
ENSP00000248244
PRO
Q8IUC6
Pharos - Targets
Q8IUC6
Orphanet
20818
PDB
4C0M
,
4BSX
,
2M1X
,
2M63
,
3RC4
,
5JEL
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHD2 TBK1
4
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
0.688
3
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