Reactome | MAPK10 [cytosol]

MAPK10 [cytosol]

Stable Identifier

R-HSA-450352

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

JNK3

Icon

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK10 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated MAPK activation (Homo sapiens)
      - Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK10 [cytosol] (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK10 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK10 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK10 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK10 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK10 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK10 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK10 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK10 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK10 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53779 MAPK10

Gene Names

MAPK10, JNK3, JNK3A, PRKM10, SAPK1B

Chain

chain:1-464

Reference Genes

BioGPS Gene:5602 MAPK10

COSMIC (genes):MAPK10 MAPK10

CTD Gene:5602 MAPK10

dbSNP Gene:5602 MAPK10

ENSEMBL:ENSG00000109339 MAPK10

ENSEMBL_homo_sapiens_GENE:ENSG00000109339.24 MAPK10

HGNC:6872 MAPK10

KEGG Gene (Homo sapiens):5602 MAPK10

Monarch:5602 MAPK10

NCBI Gene:5602 MAPK10

OMIM:602897 MAPK10

UCSC:P53779 MAPK10

Reference Transcript

Other Identifiers

214376_PM_at

214376_at

237413_PM_at

237413_at

2776659

2776661

2776663

2776665

2776667

2776669

2776671

2776756

2776757

2776758

2776759

2776760

2776761

2776762

2776763

2776765

2776767

2776773

2776795

2776796

2776797

2776798

2776799

2776800

2776801

2776802

2776803

37852_at

45430_at

5602

A_24_P810104

A_33_P3254216

GE54461

GE62730

GO:0000165

GO:0000166

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004705

GO:0004707

GO:0004708

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006468

GO:0007165

GO:0007254

GO:0009416

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0033554

GO:0036211

GO:0038095

GO:0042752

GO:0043226

GO:0048511

GO:0090398

GO:0106310

GO:0140096

HMNXSV003004267

HMNXSV003054415

Hs.13438.0.S1_3p_at

Hs.25209.0.A1_3p_at

ILMN_1659513

ILMN_1748281

ILMN_1766904

ILMN_1858387

ILMN_2256907

ILMN_2340131

PH_hs_0001294

PH_hs_0031094

TC04002620.hg

p12364

Participates

as a member of

MAPK8,9,10 [cytosol] (Homo sapiens)

Other forms of this molecule

p-T221,Y223-MAPK10 [cytosol]

p-T221,Y223-MAPK10 [nucleoplasm]

Inferred To

MAPK10 [cytosol] (Bos taurus)

MAPK10 [cytosol] (Caenorhabditis elegans)

MAPK10 [cytosol] (Canis familiaris)

MAPK10 [cytosol] (Dictyostelium discoideum)

MAPK10 [cytosol] (Drosophila melanogaster)

MAPK10 [cytosol] (Gallus gallus)

MAPK10 [cytosol] (Mus musculus)

MAPK10 [cytosol] (Rattus norvegicus)

MAPK10 [cytosol] (Saccharomyces cerevisiae)

MAPK10 [cytosol] (Schizosaccharomyces pombe)

MAPK10 [cytosol] (Sus scrofa)

Homologues of MAPK10 [cytosol] (Caenorhabditis elegans)

Homologues of MAPK10 [cytosol] (Dictyostelium discoideum)

kgb-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011530423.1, XP_016863914.1, XP_011530422.1, XP_016863913.1, XP_016863918.1, XP_005263187.1, NP_001304996.1, NP_001304997.1, XP_016863912.1, XP_016863910.1, XP_005263186.1, XP_016863919.1, NP_001304998.1, XP_006714331.1, NP_620448.1, XP_011530419.1, XP_005263192.1, NP_620446.1, NP_002744.1, XP_016863920.1, XP_011530420.1, XP_016863909.1, XP_016863915.1, XP_016863908.1, XP_016863921.1

ZINC - World Drugs

MK10_HUMAN

Guide to Pharmacology - Targets

1498

OpenTargets

ENSG00000109339

ZINC - FDA approved

MK10_HUMAN

ZINC - Substances

MK10_HUMAN

ZINC target

P53779

ZINC - Biogenic

MK10_HUMAN

PRO

P53779

PDB

7ORF, 7KSI, 4KKE, 7KSJ, 2B1P, 3OY1, 2EXC, 7YL1, 4Y5H, 4H39, 7S1N, 3OXI, 2WAJ, 7KSK, 4H36, 3G90, 2OK1, 4W4V, 3G9N, 8BZP, 3FI3, 3G9L, 7ORE, 3V6R, 3V6S, 4KKH, 6EKD, 2O2U, 8ENJ, 4KKG, 3PTG, 4W4X, 4Y46, 4Z9L, 4WHZ, 4W4W, 1PMN, 2R9S, 4X21, 3FV8, 3KVX, 4U79, 2ZDU, 2ZDT, 6EMH, 3CGO, 3TTI, 3TTJ, 1PMU, 3DA6, 1JNK, 8WGF, 1PMV, 4H3B, 3RTP, 2P33, 3FI2, 2O0U, 4W4Y, 3CGF, 6EQ9

ZINC - Investigational

MK10_HUMAN

IntEnz

2.7.11.24

HPA

ENSG00000109339-MAPK10

GeneCards

P53779

Ensembl

ENSP00000493100, ENST00000641737, ENST00000641657, ENSP00000492941, ENSP00000493049, ENSP00000493444, ENSP00000492929, ENSP00000492292, ENSP00000378586, ENST00000641724, ENST00000515650, ENST00000641207, ENSP00000492942, ENST00000642009, ENST00000641050, ENSP00000491122, ENST00000642103, ENSP00000493435, ENST00000641170, ENST00000638313, ENST00000641283, ENST00000641287, ENST00000641823, ENST00000641110, ENSP00000493450, ENSP00000493177, ENST00000641952, ENST00000640858, ENSP00000493374, ENSP00000493290, ENST00000641862, ENST00000641983, ENSP00000493270, ENSP00000492231, ENSP00000493168, ENSP00000493396, ENSP00000493045, ENSP00000491866, ENST00000639175, ENSP00000493038, ENSP00000491089, ENSP00000492903, ENST00000639234, ENSP00000491306, ENSP00000493208, ENST00000639242, ENSP00000491160, ENSP00000493008, ENSP00000493408, ENSP00000492204, ENST00000395166, ENST00000641297, ENST00000641647, ENST00000395157, ENSP00000493105, ENSP00000378595, ENST00000641051, ENST00000641803, ENST00000641410, ENSP00000493237, ENSP00000493040, ENSP00000493363, ENST00000515400, ENST00000642015, ENSP00000493013, ENST00000641943, ENST00000638225, ENST00000641911, ENST00000641902, ENST00000641274, ENST00000641157, ENSG00000109339, ENST00000641391, ENSP00000493375, ENSP00000493092, ENST00000641462, ENST00000641341, ENST00000642038, ENST00000641066, ENSP00000493072, ENSP00000424154, ENSP00000493275, ENSP00000493163, ENST00000640970, ENSP00000493001

Pharos - Targets

P53779

ZINC - Predictions - Purchasable

MK10_HUMAN

Orphanet

19563

HMDB Protein

HMDBP01533

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.755	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.609	2
UniProt:P26038 MSN	4	MSN [cytosol] (R-HSA-437350) MSN(2-448)-ALK(1064-1620) fusion [cytosol] (R-HSA-9711966) MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol] (R-HSA-9711971) p-T558-MSN [cytosol] (R-HSA-9663005)	0.527	2
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.527	2
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.508	2