Reactome | p-S271,T275-MAP2K7 [cytosol]

p-S271,T275-MAP2K7 [cytosol]

Stable Identifier

R-HSA-450353

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S271,T275-MKK7, MAP kinase kinase 7(phosphorylated), MAP2K7

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Locations in the PathwayBrowser for interactor UniProt:P45983 MAPK8

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External Reference Information

External Reference

UniProt:O14733 MAP2K7

Gene Names

MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4

Chain

initiator methionine:1, chain:2-419

Reference Genes

BioGPS Gene:5609 MAP2K7

COSMIC (genes):MAP2K7 MAP2K7

CTD Gene:5609 MAP2K7

dbSNP Gene:5609 MAP2K7

ENSEMBL:ENSG00000076984 MAP2K7

HGNC:6847 MAP2K7

KEGG Gene (Homo sapiens):5609 MAP2K7

Monarch:5609 MAP2K7

NCBI Gene:5609 MAP2K7

OMIM:603014 MAP2K7

UCSC:O14733 MAP2K7

Reference Transcript

Other Identifiers

0004760687

0004810152

11723595_s_at

11723596_a_at

11723597_at

11723598_x_at

11752702_a_at

16857799

209951_s_at

209952_s_at

226023_at

226053_at

3819264

3819265

3819266

3819274

3819275

3819277

3819279

3819281

3819283

3819285

3819286

3819287

3819288

3819289

3819290

3819291

3819292

3819293

3819294

3819295

3819296

3819297

41444_at

5609

59996_at

8025351

A_23_P78628

A_33_P3236651

GE785894

GO:0000166

GO:0000187

GO:0000287

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0004708

GO:0004713

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006259

GO:0006464

GO:0006468

GO:0006915

GO:0006950

GO:0006970

GO:0007165

GO:0007254

GO:0007257

GO:0008150

GO:0008219

GO:0008545

GO:0009058

GO:0009408

GO:0009411

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019899

GO:0019901

GO:0019903

GO:0032212

GO:0034612

GO:0034641

GO:0038095

GO:0042592

GO:0043167

GO:0043226

GO:0045893

GO:0046872

GO:0051276

GO:0051403

GO:0051973

GO:0070374

GO:1904355

Hs.110299.0.A1_3p_a_at

Hs.296234.0.A1_3p_at

Hs.296234.0.A2_3p_at

ILMN_1781104

PH_hs_0006079

TC19000140.hg

g2811125_3p_a_at

Participant Of

output

Phosphorylation of MEK7 by MEKK1

hasMember

p-MAP2K4/p-MAP2K7 [cytosol]

Other forms of this molecule

MAP2K7(?-419) [cytosol]

MAP2K7(2-?) [cytosol]

MAP2K7 [cytosol]

Inferred To

phospho-MAP2K7 [cytosol] (Canis familiaris)

phospho-MAP2K7 [cytosol] (Sus scrofa)

phospho-byr1 [cytosol] (Schizosaccharomyces pombe)

phospho-Map2k7 [cytosol] (Mus musculus)

phospho-Map2k7 [cytosol] (Rattus norvegicus)

phospho-MKK1 [cytosol] (Saccharomyces cerevisiae)

phospho-skh1 [cytosol] (Schizosaccharomyces pombe)

phospho-STE7 [cytosol] (Saccharomyces cerevisiae)

phospho-PBS2 [cytosol] (Saccharomyces cerevisiae)

phospho-map2k7 [cytosol] (Danio rerio)

phospho-map2k7 [cytosol] (Xenopus tropicalis)

phospho-MKK2 [cytosol] (Saccharomyces cerevisiae)

phospho-wis1 [cytosol] (Schizosaccharomyces pombe)

Homologues of p-S271,T275-MAP2K7 [cytosol] (Saccharomyces cerevisiae)

Homologues of p-S271,T275-MAP2K7 [cytosol] (Schizosaccharomyces pombe)

Modified Residues

Name

O-phospho-L-serine at 271

Coordinate

271

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 275

Coordinate

275

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001284484.1, NP_001284485.1, NP_660186.1

ZINC - World Drugs

MP2K7_HUMAN

OpenTargets

ENSG00000076984

ZINC - FDA approved

MP2K7_HUMAN

ZINC - Substances

MP2K7_HUMAN

ZINC - Biogenic

MP2K7_HUMAN

ZINC target

O14733

PRO

O14733

PDB

2DYL, 6QG7, 6QFR, 6QG4, 6IB0, 5B2K, 6QHR, 3WZU, 5Z1D, 6QFL, 5B2M, 5Z1E, 5Y8U, 6QFT, 6IB2, 4UX9, 5Y90, 6QHO, 5B2L

ZINC - Investigational

MP2K7_HUMAN

IntEnz

2.7.12.2

HPA

ENSG00000076984-MAP2K7

GeneCards

O14733

Ensembl

ENST00000397983, ENST00000397981, ENSP00000381068, ENST00000397979, ENSP00000381070, ENSP00000381066, ENSG00000076984

ZINC - Predictions - Purchasable

MP2K7_HUMAN

HMDB Protein

HMDBP08761

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43318 MAP3K7	10	MAP3K7 [plasma membrane] (R-HSA-9012677) PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) p-T187-MAP3K7 [cytosol] (R-HSA-206014) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.702	3
IntAct:EBI-9998887 (DTP3)-TYR,ARG,PHE			0.672	7
UniProt:O75293 GA45B			0.645	8
UniProt:Q9UQF2 JIP1			0.623	5
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [cytosol] (R-HSA-194371) MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.564	4
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.462	3

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