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MAPK9 [cytosol]
Stable Identifier
R-HSA-450355
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
JNK2
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
NPM1-ALK-dependent MAPK8,9 phosphorylation (Homo sapiens)
MAPK8,9 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P45984 MAPK9
Gene Names
MAPK9, JNK2, PRKM9, SAPK1A
Chain
chain:1-424
Reference Genes
BioGPS Gene:5601 MAPK9
COSMIC (genes):MAPK9 MAPK9
CTD Gene:5601 MAPK9
dbSNP Gene:5601 MAPK9
ENSEMBL:ENSG00000050748 MAPK9
HGNC:6886 MAPK9
KEGG:hsa:5601 MAPK9
Monarch:5601 MAPK9
NCBI Gene:5601 MAPK9
OMIM:602896 MAPK9
UCSC:P45984 MAPK9
Reference Transcript
RefSeq:XM_006714891.2 MAPK9
RefSeq:XM_017009638.1 MAPK9
RefSeq:NM_139068.2 MAPK9
RefSeq:NM_001308244.1 MAPK9
RefSeq:NM_139069.2 MAPK9
RefSeq:NM_001135044.1 MAPK9
RefSeq:NM_002752.4 MAPK9
RefSeq:NM_139070.2 MAPK9
RefSeq:XM_017009641.1 MAPK9
Participates
as a member of
MAPK8,9 [cytosol] (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
Other forms of this molecule
p-T183,Y185-MAPK9 [nucleoplasm]
p-T183,Y185-MAPK9 [cytosol]
Inferred To
Homologues of MAPK9 [cytosol]
(Caenorhabditis elegans)
Homologues of MAPK9 [cytosol]
(Dictyostelium discoideum)
MAPK9 [cytosol]
(Bos taurus)
MAPK9 [cytosol]
(Caenorhabditis elegans)
MAPK9 [cytosol]
(Canis familiaris)
MAPK9 [cytosol]
(Dictyostelium discoideum)
MAPK9 [cytosol]
(Drosophila melanogaster)
MAPK9 [cytosol]
(Gallus gallus)
MAPK9 [cytosol]
(Mus musculus)
MAPK9 [cytosol]
(Rattus norvegicus)
MAPK9 [cytosol]
(Saccharomyces cerevisiae)
MAPK9 [cytosol]
(Schizosaccharomyces pombe)
MAPK9 [cytosol]
(Sus scrofa)
kgb-2 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001128516.1
,
NP_620709.1
,
NP_001295173.1
,
XP_006714954.1
,
XP_016865130.1
,
NP_620708.1
,
NP_002743.3
,
NP_620707.1
,
XP_016865127.1
Guide to Pharmacology - Targets
1497
OpenTargets
ENSG00000050748
ENSEMBL
ENSG00000050748
,
ENSP00000345524
,
ENST00000343111
,
ENSP00000377028
,
ENSP00000394560
,
ENST00000393360
,
ENSP00000397422
,
ENSP00000389338
,
ENST00000425491
,
ENST00000455781
,
ENST00000452135
ZINC - FDA approved
MK09_HUMAN
ZINC - Substances
MK09_HUMAN
ZINC - Biogenic
MK09_HUMAN
ZINC target
P45984
PRO
P45984
GlyGen
P45984
PDB
7CML
,
3E7O
,
7N8T
,
8ELC
,
3NPC
ZINC - Investigational
MK09_HUMAN
HPA
ENSG00000050748-MAPK9
GeneCards
MAPK9
Pharos - Targets
P45984
ZINC - Predictions - Purchasable
MK09_HUMAN
HMDB Protein
HMDBP01304
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.841
9
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.841
9
UniProt:Q9BY84 DUSP16
3
Ac-55-DUSP16 [cytosol]
(R-HSA-9636576)
DUSP16 [nucleoplasm]
(R-HSA-5675337)
DUSP16 [cytosol]
(R-HSA-5675336)
0.8
8
UniProt:P15336 ATF2
2
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
ATF2 [nucleoplasm]
(R-HSA-450336)
0.781
9
UniProt:P45983 MAPK8
3
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
MAPK8 [cytosol]
(R-HSA-168141)
0.773
5
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P37231 PPARG
2
PPARG [nucleoplasm]
(R-HSA-446172)
monoSUMO1-K107,K395-PPARG [nucleoplasm]
(R-HSA-4717444)
0.556
3
UniProt:Q02548 PAX5
1
PAX5 [nucleoplasm]
(R-HSA-158583)
0.556
3
UniProt:Q13352 ITGB3BP
2
ITGB3BP [cytosol]
(R-HSA-3006405)
ITGB3BP [nucleoplasm]
(R-HSA-606325)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P45985 MAP2K4
4
MAP2K4(?-399) [cytosol]
(R-HSA-5211396)
MAP2K4(1-?) [cytosol]
(R-HSA-5211402)
p-S257,T261-MAP2K4 [cytosol]
(R-HSA-168170)
MAP2K4 [cytosol]
(R-HSA-168107)
0.547
2
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.462
3
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