Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
MAPK9 [cytosol]
Stable Identifier
R-HSA-450355
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
JNK2
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
MAPK9 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P45984 MAPK9
Gene Names
MAPK9, JNK2, PRKM9, SAPK1A
Chain
chain:1-424
Reference Genes
BioGPS Gene:5601 MAPK9
COSMIC (genes):MAPK9 MAPK9
CTD Gene:5601 MAPK9
dbSNP Gene:5601 MAPK9
ENSEMBL:ENSG00000050748 MAPK9
HGNC:6886 MAPK9
KEGG Gene (Homo sapiens):5601 MAPK9
Monarch:5601 MAPK9
NCBI Gene:5601 MAPK9
OMIM:602896 MAPK9
UCSC:P45984 MAPK9
Reference Transcript
RefSeq:XM_006714891.2 MAPK9
RefSeq:XM_017009638.1 MAPK9
RefSeq:NM_001135044.1 MAPK9
RefSeq:XM_017009641.1 MAPK9
RefSeq:NM_002752.4 MAPK9
RefSeq:NM_001308244.1 MAPK9
RefSeq:NM_139069.2 MAPK9
RefSeq:NM_139068.2 MAPK9
RefSeq:NM_139070.2 MAPK9
Other Identifiers
0005050039
0104920397
11720237_s_at
11720238_at
11720239_a_at
11740489_at
1238_at
17003898
203218_at
210570_x_at
225781_at
2890602
2890604
2890606
2890607
2890608
2890609
2890610
2890611
2890612
2890613
2890614
2890618
2890619
2890622
2890624
2890627
2890628
2890629
2890632
2890635
2890639
2890640
2890641
2890643
2890647
2890648
2890652
2890655
38431_at
45319_at
52185_at
5601
8116402
A_23_P167692
A_33_P3400192
GE58908
GE81189
GO:0000166
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004705
GO:0004707
GO:0004712
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0006464
GO:0006468
GO:0006950
GO:0007165
GO:0007254
GO:0007258
GO:0008134
GO:0008150
GO:0008219
GO:0009056
GO:0009058
GO:0010468
GO:0010628
GO:0010744
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0022607
GO:0030154
GO:0031398
GO:0034614
GO:0034641
GO:0035556
GO:0038095
GO:0042752
GO:0043167
GO:0043226
GO:0046686
GO:0048511
GO:0051090
GO:0061833
GO:0065003
GO:0071276
GO:0071803
GO:1901485
GO:2001235
Hs.246857.2.A1_3p_at
ILMN_1795411
ILMN_2400292
ILMN_2400297
PH_hs_0023911
TC05002145.hg
U09759_at
g1463132_3p_a_at
Participant Of
hasMember
MAPK8,9,10 [cytosol]
Other forms of this molecule
p-T183,Y185-MAPK9 [cytosol]
p-T183,Y185-MAPK9 [nucleoplasm]
Inferred To
mapk9 [cytosol] (Danio rerio)
kgb-1 [cytosol] (Caenorhabditis elegans)
MAPK9 [cytosol] (Bos taurus)
MAPK9 [cytosol] (Caenorhabditis elegans)
MAPK9 [cytosol] (Canis familiaris)
MAPK9 [cytosol] (Dictyostelium discoideum)
MAPK9 [cytosol] (Gallus gallus)
MAPK9 [cytosol] (Plasmodium falciparum)
MAPK9 [cytosol] (Sus scrofa)
bsk [cytosol] (Drosophila melanogaster)
erkA [cytosol] (Dictyostelium discoideum)
HOG1 [cytosol] (Saccharomyces cerevisiae)
kgb-2 [cytosol] (Caenorhabditis elegans)
Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
Homologues of MAPK9 [cytosol] (Dictyostelium discoideum)
Homologues of MAPK9 [cytosol] (Plasmodium falciparum)
Homologues of MAPK9 [cytosol] (Saccharomyces cerevisiae)
Homologues of MAPK9 [cytosol] (Schizosaccharomyces pombe)
Mapk9 [cytosol] (Mus musculus)
Mapk9 [cytosol] (Rattus norvegicus)
spm1 [cytosol] (Schizosaccharomyces pombe)
jnk-1 [cytosol] (Caenorhabditis elegans)
SMK1 [cytosol] (Saccharomyces cerevisiae)
sty1 [cytosol] (Schizosaccharomyces pombe)
SLT2 [cytosol] (Saccharomyces cerevisiae)
Cross References
RefSeq
XP_016865130.1
,
XP_006714954.1
,
NP_001295173.1
,
NP_620708.1
,
NP_001128516.1
,
XP_016865127.1
,
NP_620707.1
,
NP_620709.1
,
NP_002743.3
ZINC - World Drugs
MK09_HUMAN
OpenTargets
ENSG00000050748
ZINC - FDA approved
MK09_HUMAN
ZINC - Substances
MK09_HUMAN
ZINC target
P45984
ZINC - Biogenic
MK09_HUMAN
PRO
P45984
PDB
3NPC
,
3E7O
ZINC - Investigational
MK09_HUMAN
Target Pathogen
5b354852be737e166372eb7c
IntEnz
2.7.11.24
HPA
ENSG00000050748-MAPK9
GeneCards
P45984
Ensembl
ENSP00000345524
,
ENSG00000050748
,
ENSP00000389338
,
ENST00000393360
,
ENSP00000397422
,
ENSP00000377028
,
ENST00000455781
,
ENSP00000394560
,
ENST00000343111
,
ENST00000452135
,
ENST00000425491
ZINC - Predictions - Purchasable
MK09_HUMAN
HMDB Protein
HMDBP01304
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32121 ARRB2
2
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [cytosol]
(R-HSA-416464)
0.841
9
UniProt:P49407 ARRB1
5
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [cytosol]
(R-HSA-264470)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.841
9
UniProt:P15336 ATF2
2
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
ATF2 [nucleoplasm]
(R-HSA-450336)
0.781
9
UniProt:Q02548 PAX5
1
PAX5 [nucleoplasm]
(R-HSA-158583)
0.556
3
UniProt:P37231 PPARG
2
PPARG [nucleoplasm]
(R-HSA-446172)
SUMO1-K107,K395-PPARG [nucleoplasm]
(R-HSA-4717444)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:P14136 GFAP
3
GFAP [lysosomal membrane]
(R-HSA-9625195)
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.556
3
UniProt:Q9BY84 DUSP16
3
DUSP16 [nucleoplasm]
(R-HSA-5675337)
Ac-55-DUSP16 [cytosol]
(R-HSA-9636576)
DUSP16 [cytosol]
(R-HSA-5675336)
0.556
5
UniProt:Q13352 ITGB3BP
2
ITGB3BP [nucleoplasm]
(R-HSA-606325)
ITGB3BP [cytosol]
(R-HSA-3006405)
0.556
3
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.553
2
UniProt:P45983 MAPK8
3
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
MAPK8 [cytosol]
(R-HSA-168141)
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
0.527
2
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
0.462
3
© 2020
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
![MAPK9 [cytosol] icon](/icon/R-ICO-013675.svg){kind=icon}
