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p-S54,S92,S203-p-ZFP36L1 [cytosol]
Stable Identifier
R-HSA-450384
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S203,S54,S92-p-ZFP36L1, Butyrate response factor 1 with phosphoserine54, phosphoserine92, and phosphoserine203, ZFP36L1, TISB_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Homo sapiens)
MK2 phosphorylates BRF1 (Homo sapiens)
Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA Complex [cytosol] (Homo sapiens)
p-S54,S92,S203-p-ZFP36L1 [cytosol] (Homo sapiens)
p-S54,92,203-BRF1 binds 14-3-3 (Homo sapiens)
Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA Complex [cytosol] (Homo sapiens)
p-S54,S92,S203-p-ZFP36L1 [cytosol] (Homo sapiens)
Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA:14-3-3 Complex [cytosol] (Homo sapiens)
Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA Complex [cytosol] (Homo sapiens)
p-S54,S92,S203-p-ZFP36L1 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17030608
BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites
Gross, B
,
Benjamin, D
,
Min, L
,
Moroni, C
,
Schmidlin, M
Mol Cell Biol
2006
External Reference Information
External Reference
UniProt:Q07352 ZFP36L1
Gene Names
ZFP36L1, BERG36, BRF1, ERF1, RNF162B, TIS11B
Chain
chain:1-338
Reference Genes
BioGPS Gene:677 ZFP36L1
COSMIC (genes):BRF1 ZFP36L1
COSMIC (genes):ZFP36L1 ZFP36L1
CTD Gene:677 ZFP36L1
dbSNP Gene:677 ZFP36L1
ENSEMBL:ENSG00000185650 ZFP36L1
HGNC:1107 ZFP36L1
Monarch:677 ZFP36L1
NCBI Gene:677 ZFP36L1
OMIM:601064 ZFP36L1
UCSC:Q07352 ZFP36L1
Reference Transcript
RefSeq:NM_001244701.1 ZFP36L1
RefSeq:NM_004926.3 ZFP36L1
RefSeq:NM_001244698.1 ZFP36L1
Other Identifiers
11716115_s_at
11726889_at
11746561_a_at
11746562_x_at
11749937_x_at
11758557_s_at
16794158
211962_PM_s_at
211962_s_at
211965_PM_at
211965_at
213277_PM_at
213277_at
229054_PM_at
229054_at
3569755
3569756
3569757
3569758
3569759
3569760
3569761
3569762
3569763
3569764
3569765
3569766
3569773
3569774
3569775
3569776
3569777
3569779
3569780
3569781
3569782
3569783
3569784
3569785
38740_at
47134_at
677
7979813
7979820
89246_at
92029_at
A_23_P406071
A_23_P99540
A_24_P99152
A_33_P3355717
A_33_P3417865
GE60046
GE85365
GO:0000165
GO:0000288
GO:0000932
GO:0001570
GO:0002376
GO:0003342
GO:0003677
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006397
GO:0006402
GO:0006417
GO:0006915
GO:0007155
GO:0007507
GO:0008283
GO:0009611
GO:0010468
GO:0010837
GO:0012501
GO:0016071
GO:0021915
GO:0030154
GO:0031086
GO:0031440
GO:0032869
GO:0033077
GO:0035264
GO:0035925
GO:0038066
GO:0043226
GO:0043488
GO:0043491
GO:0044344
GO:0045577
GO:0045600
GO:0045616
GO:0045647
GO:0045657
GO:0045661
GO:0046872
GO:0048382
GO:0048568
GO:0048856
GO:0051028
GO:0060710
GO:0060712
GO:0061014
GO:0061158
GO:0070371
GO:0071320
GO:0071356
GO:0071364
GO:0071375
GO:0071385
GO:0071456
GO:0071472
GO:0071560
GO:0071889
GO:0072091
GO:0097403
GO:1900153
GO:1901991
GO:1902172
GO:1904582
GO:1990904
HMNXSV003016002
HMNXSV003048516
Hs.85155.0.S1_3p_at
Hs.85155.0.S1_3p_x_at
Hs.85155.0.S2_3p_a_at
Hs.85155.1.S1_3p_at
Hs.87912.0.A1_3p_at
ILMN_1675448
ILMN_1689560
PH_hs_0004816
PH_hs_0004929
PH_hs_0031378
TC14001253.hg
TC14001254.hg
X79067_at
g10242378_3p_s_at
Participates
as a component of
Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA Complex [cytosol] (Homo sapiens)
Other forms of this molecule
ZFP36L1 [cytosol]
p-S92,S203-ZFP36L1 [cytosol]
Inferred To
phospho-Zfp36l1 [cytosol]
(Gallus gallus)
phospho-Zfp36l1 [cytosol]
(Mus musculus)
phospho-Zfp36l1 [cytosol]
(Rattus norvegicus)
phospho-oma-2 [cytosol]
(Caenorhabditis elegans)
phospho-mex-1 [cytosol]
(Caenorhabditis elegans)
phospho-oma-1 [cytosol]
(Caenorhabditis elegans)
phospho-ZFP36L1 [cytosol]
(Bos taurus)
phospho-ZFP36L1 [cytosol]
(Canis familiaris)
phospho-ZFP36L1 [cytosol]
(Sus scrofa)
phospho-dct-13 [cytosol]
(Caenorhabditis elegans)
phospho-ccch-2 [cytosol]
(Caenorhabditis elegans)
Homologues of p-S54,S92,S203-p-ZFP36L1 [cytosol]
(Caenorhabditis elegans)
Homologues of p-S54,S92,S203-p-ZFP36L1 [cytosol]
(Saccharomyces cerevisiae)
phospho-Tis11 [cytosol]
(Drosophila melanogaster)
phospho-p-S54,S92,S203-p-ZFP36L1 [cytosol]
(Caenorhabditis elegans)
phospho-p-S54,S92,S203-p-ZFP36L1 [cytosol]
(Dictyostelium discoideum)
phospho-ccch-1 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of p-S54,S92,S203-p-ZFP36L1 [cytosol]
(Xenopus tropicalis)
phospho-pie-1 [cytosol]
(Caenorhabditis elegans)
phospho-zfp36l1b [cytosol]
(Danio rerio)
phospho-CTH1 [cytosol]
(Saccharomyces cerevisiae)
phospho-mex-5 [cytosol]
(Caenorhabditis elegans)
phospho-mex-6 [cytosol]
(Caenorhabditis elegans)
phospho-zfs1 [cytosol]
(Schizosaccharomyces pombe)
phospho-ccch-5 [cytosol]
(Caenorhabditis elegans)
phospho-moe-3 [cytosol]
(Caenorhabditis elegans)
phospho-TIS11 [cytosol]
(Saccharomyces cerevisiae)
Modified Residues
Name
O-phospho-L-serine at 92
Coordinate
92
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 203
Coordinate
203
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 54
Coordinate
54
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
ENSEMBL
ENST00000336440
,
ENST00000439696
,
ENSP00000388402
,
ENSP00000337386
OpenTargets
ENSG00000185650
HPA
ENSG00000185650-ZFP36L1
PRO
Q07352
Pharos - Targets
Q07352
PDB
1W0V
,
1W0W
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.529
4
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
2
UniProt:Q16539 MAPK14
7
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.508
2
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