p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta

Stable Identifier
R-HSA-450394
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylated tristetraproline (TTP) binds 14-3-3, which inhibits the ability of TTP to destabilize RNA. Thus RNAs bound by TTP become stabilized. The binding of 14-3-3 causes TTP to be excluded from stress granules.

Literature References
PubMed ID Title Journal Year
15014438 MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

Stoecklin, G, Stubbs, T, Kedersha, N, Wax, S, Rigby, WF, Blackwell, TK, Anderson, P

EMBO J 2004
18481987 Control of mRNA decay by phosphorylation of tristetraprolin

Sandler, H, Stoecklin, G

Biochem Soc Trans 2008
14688255 MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding

Chrestensen, CA, Schroeder, MJ, Shabanowitz, J, Hunt, DF, Pelo, JW, Worthington, MT, Sturgill, TW

J Biol Chem 2004
15944294 Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function

Rigby, WF, Roy, K, Collins, J, Rigby, S, Connolly, JE, Bloch, DB, Brooks, SA

J Immunol 2005
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