Reactome: A Curated Pathway Database

ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs

Stable Identifier
R-HSA-450400
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Tristetraprolin (TTP) binds UUAUUUAUU motifs in the AU-rich elements of mRNAs. TTP binds Transportin-1 (Importin beta-2) which plays a role in shuttling TTP between P-bodies and stress granules.

Literature References
PubMed ID Title Journal Year
19729507 A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay Nucleic Acids Res 2009
18367721 Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation RNA 2008
12646273 Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases Arch Biochem Biophys 2003
17133347 Tristetraprolin recruits functional mRNA decay complexes to ARE sequences J Cell Biochem 2007
12324455 RNA binding properties of the AU-rich element-binding recombinant Nup475/TIS11/tristetraprolin protein J Biol Chem 2002
15117938 RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs J Biol Chem 2004
12705825 Selective RNA binding by a single CCCH zinc-binding domain from Nup475 (Tristetraprolin) Biochemistry 2003
12639954 Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates J Biol Chem 2003
10330172 Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA Mol Cell Biol 1999
17369404 TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements Genes Dev 2007
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