KSRP recruits RNA degradation activities

Stable Identifier
R-HSA-450422
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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KSRP (KHSRP) forms a complex with the PARN deadenylase, exosome components (3' to 5' mRNA decay), and the decapping enzyme DCP2. Tethering KSRP to a mRNA is sufficient to target the mRNA for degradation.

Literature References
PubMed ID Title Journal Year
15175153 A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery

Gherzi, R, Lee, KY, Briata, P, Wegmüller, D, Moroni, C, Karin, M, Chen, CY

Mol Cell 2004
11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Chen, CY, Gherzi, R, Ong, SE, Chan, EL, Raijmakers, R, Pruijn, GJ, Stoecklin, G, Moroni, C, Mann, M, Karin, M

Cell 2001
16648466 Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay

Chou, CF, Mulky, A, Maitra, S, Lin, WJ, Gherzi, R, Kappes, J, Chen, CY

Mol Cell Biol 2006
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