Reactome: A Curated Pathway Database

ZFP36 (TTP) recruits RNA degradation activities

Stable Identifier
R-HSA-450431
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TTP interacts directly with exonucleases (XRN1 and the exosome) and decapping enzymes (DCP1a and DCP2) which hydrolyze the mRNA bound by TTP. TTP also recruits PARN deadenylase, however a direct interaction between TTP and PARN has not been demonstrated.

Literature References
Participants
Participant Of