ZFP36 (TTP) recruits RNA degradation activities

Stable Identifier
R-HSA-450431
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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Summation

TTP interacts directly with exonucleases (XRN1 and the exosome) and decapping enzymes (DCP1a and DCP2) which hydrolyze the mRNA bound by TTP. TTP also recruits PARN deadenylase, however a direct interaction between TTP and PARN has not been demonstrated.

Literature References
PubMed ID Title Journal Year
12748283 Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease

Lai, WS, Kennington, EA, Blackshear, PJ

Mol Cell Biol 2003
11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Chen, CY, Gherzi, R, Ong, SE, Chan, EL, Raijmakers, R, Pruijn, GJ, Stoecklin, G, Moroni, C, Mann, M, Karin, M

Cell 2001
17133347 Tristetraprolin recruits functional mRNA decay complexes to ARE sequences

Hau, HH, Walsh, RJ, Ogilvie, RL, Williams, DA, Reilly, CS, Bohjanen, PR

J Cell Biochem 2007
15687258 Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1

Lykke-Andersen, J, Wagner, E

Genes Dev 2005
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