Reactome | ZFP36 (TTP) recruits RNA degradation activities

ZFP36 (TTP) recruits RNA degradation activities

Stable Identifier

R-HSA-450431

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Summation

TTP interacts directly with exonucleases (XRN1 and the exosome) and decapping enzymes (DCP1a and DCP2) which hydrolyze the mRNA bound by TTP. TTP also recruits PARN deadenylase, however a direct interaction between TTP and PARN has not been demonstrated.

Literature References

PubMed ID	Title	Journal	Year
12748283	Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease	Mol Cell Biol	2003
11719186	AU binding proteins recruit the exosome to degrade ARE-containing mRNAs	Cell	2001
17133347	Tristetraprolin recruits functional mRNA decay complexes to ARE sequences	J Cell Biochem	2007
15687258	Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1	Genes Dev	2005

Participants

Input

Output

TTP:mRNA Degradation Complex [cytosol] (Homo sapiens)

Participant Of

hasEvent

Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA