ZFP36 (TTP) recruits RNA degradation activities

Stable Identifier
R-HSA-450431
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TTP interacts directly with exonucleases (XRN1 and the exosome) and decapping enzymes (DCP1a and DCP2) which hydrolyze the mRNA bound by TTP. TTP also recruits PARN deadenylase, however a direct interaction between TTP and PARN has not been demonstrated.

Literature References
PubMed ID Title Journal Year
12748283 Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease

Lai, WS, Kennington, EA, Blackshear, PJ

Mol Cell Biol 2003
11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Chen, CY, Gherzi, R, Ong, SE, Chan, EL, Raijmakers, R, Pruijn, GJ, Stoecklin, G, Moroni, C, Mann, M, Karin, M

Cell 2001
17133347 Tristetraprolin recruits functional mRNA decay complexes to ARE sequences

Hau, HH, Walsh, RJ, Ogilvie, RL, Williams, DA, Reilly, CS, Bohjanen, PR

J Cell Biochem 2007
15687258 Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1

Lykke-Andersen, J, Wagner, E

Genes Dev 2005
Participants
Participant Of
Authored
Reviewed