Reactome | ZFP36 (TTP) recruits RNA degradation activities

ZFP36 (TTP) recruits RNA degradation activities

Stable Identifier

R-HSA-450431

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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ZFP36 (TTP) recruits RNA degradation activities

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TTP interacts directly with exonucleases (XRN1 and the exosome) and decapping enzymes (DCP1a and DCP2) which hydrolyze the mRNA bound by TTP. TTP also recruits PARN deadenylase, however a direct interaction between TTP and PARN has not been demonstrated.

Literature References

PubMed ID	Title	Journal	Year
12748283	Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease Lai, WS, Kennington, EA, Blackshear, PJ	Mol Cell Biol	2003
11719186	AU binding proteins recruit the exosome to degrade ARE-containing mRNAs Chen, CY, Gherzi, R, Ong, SE, Chan, EL, Raijmakers, R, Pruijn, GJ, Stoecklin, G, Moroni, C, Mann, M, Karin, M	Cell	2001
17133347	Tristetraprolin recruits functional mRNA decay complexes to ARE sequences Hau, HH, Walsh, RJ, Ogilvie, RL, Williams, DA, Reilly, CS, Bohjanen, PR	J Cell Biochem	2007
15687258	Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1 Lykke-Andersen, J, Wagner, E	Genes Dev	2005