Reactome | p-S193-KHSRP [nucleoplasm]

p-S193-KHSRP [nucleoplasm]

Stable Identifier

R-HSA-450452

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

KSRP with phosphoserine193, Far upstream element-binding protein 2, KHSRP, FUBP2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q92945 KHSRP

Gene Names

KHSRP, FUBP2

Chain

initiator methionine:, chain:2-711

Reference Genes

BioGPS Gene:8570 KHSRP

COSMIC (genes):KHSRP KHSRP

CTD Gene:8570 KHSRP

dbSNP Gene:8570 KHSRP

ENSEMBL:ENSG00000088247 KHSRP

ENSEMBL_homo_sapiens_GENE:ENSG00000088247.19 KHSRP

HGNC:6316 KHSRP

KEGG Gene (Homo sapiens):8570 KHSRP

Monarch:8570 KHSRP

NCBI Gene:8570 KHSRP

OMIM:603445 KHSRP

UCSC:Q92945 KHSRP

Reference Transcript

RefSeq:NM_003685.2 KHSRP

Other Identifiers

11743521_s_at

11746598_a_at

11754264_a_at

11757710_x_at

16867680

204371_PM_s_at

204371_s_at

204372_PM_s_at

204372_s_at

212303_PM_x_at

3164890

3164892

3164893

3164899

3164901

3847815

3847816

3847817

3847818

3847819

3847822

3847823

3847825

3847826

3847828

3847830

3847832

3847834

3847836

3847837

3847839

3847840

3847841

3847842

3847843

3847844

3847845

3847846

3847847

3847848

3847851

3847852

3847853

38828_s_at

38829_r_at

8033162

8570

A_23_P16157

A_24_P134235

GE59589

GO:0000178

GO:0000375

GO:0003676

GO:0003677

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006397

GO:0006457

GO:0008380

GO:0010468

GO:0010586

GO:0010989

GO:0016020

GO:0016071

GO:0035925

GO:0043226

GO:0043488

GO:0044183

GO:0045019

GO:0051028

GO:0061014

GO:0061158

GO:0071345

HMNXSV003026154

Hs.91142.0.S1_3p_a_at

ILMN_1673936

PH_hs_0005071

TC19001095.hg

TC19002305.hg

U69126_s_at

U94832_at

g4504864_3p_a_at

Participates

as a component of

Phosphorylated KSRP (Ser193):14-3-3zeta Complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-T692-KHSRP [cytosol]

p-S193-KHSRP [cytosol]

KSRP [cytosol]

Inferred To

phospho-khsrp [nucleoplasm] (Danio rerio)

phospho-khsrp [nucleoplasm] (Xenopus tropicalis)

phospho-Khsrp [nucleoplasm] (Mus musculus)

phospho-Khsrp [nucleoplasm] (Rattus norvegicus)

phospho-KHSRP [nucleoplasm] (Canis familiaris)

phospho-KHSRP [nucleoplasm] (Sus scrofa)

phospho-p-S193-KHSRP [nucleoplasm] (Bos taurus)

phospho-p-S193-KHSRP [nucleoplasm] (Caenorhabditis elegans)

phospho-fubl-2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of p-S193-KHSRP [nucleoplasm] (Caenorhabditis elegans)

phospho-fubl-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-fubl-3 [nucleoplasm] (Caenorhabditis elegans)

phospho-fubl-4 [nucleoplasm] (Caenorhabditis elegans)

phospho-Psi [nucleoplasm] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-serine at 193

Coordinate

193

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_003676.2

OpenTargets

ENSG00000088247

HPA

ENSG00000088247-KHSRP

GeneCards

Q92945

Ensembl

ENSG00000088247, ENST00000398148, ENSP00000381216

PRO

Q92945

Pharos - Targets

Q92945

PDB

2JVZ, 4B8T, 2OPV, 2HH2, 2OPU, 2HH3

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63101 Ywhaz	3	14-3-3zeta [cytosol] (R-MMU-206177) Ywhaz [nucleoplasm] (R-MMU-450469) Ywhaz [cytosol] (R-MMU-206099)	0.592	2
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.564	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9
UniProt:P49312	1	Hnrnpa1 [nucleoplasm] (R-MMU-71927)	0.482	2
UniProt:Q60668	5	Hnrnpd [cytosol] (R-MMU-451232) phospho-Hnrnpd [cytosol] (R-MMU-451223) Hnrnpd [cytosol] (R-MMU-450442) phospho-Hnrnpd [cytosol] (R-MMU-450602) Hnrnpd [nucleoplasm] (R-MMU-71935)	0.482	2
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.462	3

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