MK2 phosphorylates ZFP36 (Tristetraproline, TTP)

Stable Identifier
R-HSA-450463
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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TTP is phosphorylated by MK2 at serines 60 and 186.

Literature References
PubMed ID Title Journal Year
14688255 MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding

Chrestensen, CA, Schroeder, MJ, Shabanowitz, J, Hunt, DF, Pelo, JW, Worthington, MT, Sturgill, TW

J Biol Chem 2004
18481987 Control of mRNA decay by phosphorylation of tristetraprolin

Sandler, H, Stoecklin, G

Biochem Soc Trans 2008
15014438 MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

Stoecklin, G, Stubbs, T, Kedersha, N, Wax, S, Rigby, WF, Blackwell, TK, Anderson, P

EMBO J 2004
15944294 Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function

Rigby, WF, Roy, K, Collins, J, Rigby, S, Connolly, JE, Bloch, DB, Brooks, SA

J Immunol 2005
16262601 Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis

Cao, H, Deterding, LJ, Venable, JD, Kennington, EA, Yates, JR 3rd, Tomer, KB, Blackshear, PJ

Biochem J 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S272,T222,T334-MAPKAPK2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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