MK2 phosphorylates BRF1

Stable Identifier
R-HSA-450474
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MAPK-activated protein kinase 2 (MK2) phosphorylates BRF1 at serine 54, serine 92, serine 203, and an unknown site in the C terminus. Phosphorylation inhibits the ability of BRF1 to cause degradation of RNA. It is unknown if tetraphosphorylated BRF1 binds 14-3-3 in the same way as diphosphorylated BRF1 does.

Literature References
PubMed ID Title Journal Year
18326031 The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2

Maitra, S, Chou, CF, Luber, CA, Lee, KY, Mann, M, Chen, CY

RNA 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S272,T222,T334-MAPKAPK2 [cytosol]
Physical Entity
Activity
Orthologous Events
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Created