Protein Kinase B/Akt phosphorylates BRF1

Stable Identifier
R-HSA-450490
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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BRF1 is phosphorylated at Serine92 and Serine203 by Protein kinase B/AKT. Protein kinase B is activated by phosphatidylinositol 3-kinase. Phosphorylation of BRF1 does not interfere with the ability of BRF1 to bind RNA or interact with enzymes that catalyze RNA degradation therefore larger complexes may contain phosphorylated BRF1.

Literature References
PubMed ID Title Journal Year
15538381 The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B

Schmidlin, M, Lu, M, Leuenberger, SA, Stoecklin, G, Mallaun, M, Gross, B, Gherzi, R, Hess, D, Hemmings, BA, Moroni, C

EMBO J 2004
17030608 BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites

Benjamin, D, Schmidlin, M, Min, L, Gross, B, Moroni, C

Mol Cell Biol 2006
12198173 Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover

Stoecklin, G, Colombi, M, Raineri, I, Leuenberger, S, Mallaun, M, Schmidlin, M, Gross, B, Lu, M, Kitamura, T, Moroni, C

EMBO J 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created