HuR binds mRNAs in the nucleus

Stable Identifier
R-HSA-450494
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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HuR binds AU-rich elements of mRNAs. Bound HuR can form oligomers on longer AU-rich elements. Phosphorylated HuR binds mRNA more tightly than unphosphorylated HuR does.

Literature References
PubMed ID Title Journal Year
17517897 Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences

Fialcowitz-White, EJ, Brewer, BY, Ballin, JD, Willis, CD, Toth, EA, Wilson, GM

J Biol Chem 2007
16484227 Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element

Prechtel, AT, Chemnitz, J, Schirmer, S, Ehlers, C, Langbein-Detsch, I, Stülke, J, Dabauvalle, MC, Kehlenbach, RH, Hauber, J

J Biol Chem 2006
14981256 Identification of a target RNA motif for RNA-binding protein HuR

López de Silanes, I, Zhan, M, Lal, A, Yang, X, Gorospe, M

Proc Natl Acad Sci U S A 2004
11834731 A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR

Goldberg-Cohen, I, Furneauxb, H, Levy, AP

J Biol Chem 2002
11018049 Protein ligands to HuR modulate its interaction with target mRNAs in vivo

Brennan, CM, Gallouzi, IE, Steitz, JA

J Cell Biol 2000
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