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p-S193-KHSRP [cytosol]
Stable Identifier
R-HSA-450505
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
KSRP with phosphoserine193, Far upstream element-binding protein 2, KHSRP, FUBP2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P05412 JUN
Expand all
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
KSRP (KHSRP) binds and destabilizes mRNA (Homo sapiens)
Protein Kinase B (AKT) phosphorylates KSRP (Homo sapiens)
p-S193-KHSRP [cytosol] (Homo sapiens)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Homo sapiens)
p-S193-KHSRP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92945 KHSRP
Gene Names
KHSRP, FUBP2
Chain
initiator methionine:1, chain:2-711
Reference Genes
BioGPS Gene:8570 KHSRP
COSMIC (genes):KHSRP KHSRP
CTD Gene:8570 KHSRP
dbSNP Gene:8570 KHSRP
ENSEMBL:ENSG00000088247 KHSRP
ENSEMBL:ENSG00000088247.19 KHSRP
HGNC:6316 KHSRP
KEGG Gene (Homo sapiens):8570 KHSRP
Monarch:8570 KHSRP
NCBI Gene:8570 KHSRP
OMIM:603445 KHSRP
UCSC:Q92945 KHSRP
Reference Transcript
RefSeq:NM_003685.2 KHSRP
Other Identifiers
11743521_s_at
11746598_a_at
11754264_a_at
11757710_x_at
16867680
204371_PM_s_at
204371_s_at
204372_PM_s_at
204372_s_at
212303_PM_x_at
3164890
3164892
3164893
3164899
3164901
3847815
3847816
3847817
3847818
3847819
3847822
3847823
3847825
3847826
3847828
3847830
3847832
3847834
3847836
3847837
3847839
3847840
3847841
3847842
3847843
3847844
3847845
3847846
3847847
3847848
3847851
3847852
3847853
38828_s_at
38829_r_at
8033162
8570
A_23_P16157
A_24_P134235
GE59589
GO:0000178
GO:0000375
GO:0003676
GO:0003677
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006397
GO:0006457
GO:0008380
GO:0010468
GO:0010586
GO:0010989
GO:0016020
GO:0016071
GO:0035925
GO:0043226
GO:0043488
GO:0044183
GO:0045019
GO:0051028
GO:0061014
GO:0061158
GO:0071345
GO:0110165
HMNXSV003026154
Hs.91142.0.S1_3p_a_at
ILMN_1673936
PH_hs_0005071
TC19001095.hg
TC19002305.hg
U69126_s_at
U94832_at
g4504864_3p_a_at
Participates
as an input of
p-S193-KSRP binds 14-3-3zeta in the nucleus (Homo sapiens)
as an output of
Protein Kinase B (AKT) phosphorylates KSRP (Homo sapiens)
Other forms of this molecule
p-S193-KHSRP [nucleoplasm]
p-T692-KHSRP [cytosol]
KSRP [cytosol]
Inferred To
phospho-Khsrp [cytosol]
(Mus musculus)
phospho-Khsrp [cytosol]
(Rattus norvegicus)
phospho-fubl-1 [cytosol]
(Caenorhabditis elegans)
phospho-tofu-7 [cytosol]
(Caenorhabditis elegans)
phospho-Psi [cytosol]
(Drosophila melanogaster)
phospho-fubl-4 [cytosol]
(Caenorhabditis elegans)
phospho-p-S193-KHSRP [cytosol]
(Canis familiaris)
phospho-p-S193-KHSRP [cytosol]
(Danio rerio)
phospho-p-S193-KHSRP [cytosol]
(Plasmodium falciparum)
phospho-fubl-2 [cytosol]
(Caenorhabditis elegans)
phospho-fubl-3 [cytosol]
(Caenorhabditis elegans)
Homologues of p-S193-KHSRP [cytosol]
(Caenorhabditis elegans)
phospho-khsrp [cytosol]
(Xenopus tropicalis)
phospho-KHSRP [cytosol]
(Bos taurus)
phospho-KHSRP [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 193
Coordinate
193
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_003676.2
OpenTargets
ENSG00000088247
HPA
ENSG00000088247-KHSRP
GeneCards
Q92945
Ensembl
ENST00000398148
,
ENSG00000088247
,
ENSP00000381216
PRO
Q92945
Pharos - Targets
Q92945
PDB
2HH3
,
2JVZ
,
2HH2
,
2OPU
,
2OPV
,
4B8T
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63101 Ywhaz
3
14-3-3zeta [cytosol]
(R-MMU-206177)
Ywhaz [nucleoplasm]
(R-MMU-450469)
Ywhaz [cytosol]
(R-MMU-206099)
0.592
2
UniProt:P60520 GABARAPL2
3
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [cytosol]
(R-HSA-5671758)
0.564
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q60668
5
Hnrnpd [cytosol]
(R-MMU-451232)
phospho-Hnrnpd [cytosol]
(R-MMU-451223)
Hnrnpd [cytosol]
(R-MMU-450442)
phospho-Hnrnpd [cytosol]
(R-MMU-450602)
Hnrnpd [nucleoplasm]
(R-MMU-71935)
0.482
2
UniProt:P49312
1
Hnrnpa1 [nucleoplasm]
(R-MMU-71927)
0.482
2
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.462
3
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