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p-S221,S318-ELAVL1 [nucleoplasm]
Stable Identifier
R-HSA-450532
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HuR with phosphoserine221 and phosphoserine318, ELAV-like protein 1, ELAV1_HUMAN, ELAVL1, HuR
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
HuR (ELAVL1) binds and stabilizes mRNA (Homo sapiens)
HuR binds the CRM1 nuclear export machinery (Homo sapiens)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Homo sapiens)
HuR:mRNA complexes [nucleoplasm] (Homo sapiens)
HuR with phosphoserine221 and phosphoserine318:mRNA Complex [nucleoplasm] (Homo sapiens)
p-S221,S318-ELAVL1 [nucleoplasm] (Homo sapiens)
HuR:mRNA complexes [nucleoplasm] (Homo sapiens)
HuR with phosphoserine221 and phosphoserine318:mRNA Complex [nucleoplasm] (Homo sapiens)
p-S221,S318-ELAVL1 [nucleoplasm] (Homo sapiens)
HuR:mRNA complex translocates from the nucleus to the cytosol (Homo sapiens)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Homo sapiens)
HuR:mRNA complexes [nucleoplasm] (Homo sapiens)
HuR with phosphoserine221 and phosphoserine318:mRNA Complex [nucleoplasm] (Homo sapiens)
p-S221,S318-ELAVL1 [nucleoplasm] (Homo sapiens)
PKCdelta phosphorylates HuR (Homo sapiens)
p-S221,S318-ELAVL1 [nucleoplasm] (Homo sapiens)
p-S318,221-HuR binds mRNA (Homo sapiens)
HuR with phosphoserine221 and phosphoserine318:mRNA Complex [nucleoplasm] (Homo sapiens)
p-S221,S318-ELAVL1 [nucleoplasm] (Homo sapiens)
p-S221,S318-ELAVL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15717 ELAVL1
Gene Names
ELAVL1, HUR
Chain
initiator methionine:, chain:2-326
Reference Genes
BioGPS Gene:1994 ELAVL1
COSMIC (genes):ELAVL1 ELAVL1
CTD Gene:1994 ELAVL1
dbSNP Gene:1994 ELAVL1
ENSEMBL:ENSG00000066044 ELAVL1
HGNC:3312 ELAVL1
KEGG:hsa:1994 ELAVL1
Monarch:1994 ELAVL1
NCBI Gene:1994 ELAVL1
OMIM:603466 ELAVL1
UCSC:Q15717 ELAVL1
Reference Transcript
RefSeq:NM_001419.2 ELAVL1
Other Identifiers
11716528_at
11716529_a_at
11716530_at
11716531_at
11747207_a_at
16868053
1994
201726_PM_at
201726_at
201727_PM_s_at
201727_s_at
227746_PM_at
227746_at
244660_PM_at
244660_at
3848687
3848688
3848690
3848691
3848692
3848693
3848694
3848695
3848696
3848697
3848698
3848699
3848700
3848701
3848702
3848705
3848709
3848711
3848712
3848720
3848721
3848734
3848741
39384_at
59058_at
59834_at
8033479
A_23_P208477
A_23_P388681
A_32_P200165
GE59120
GE787419
GO:0000512
GO:0000932
GO:0003676
GO:0003723
GO:0003725
GO:0003729
GO:0003730
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005829
GO:0006606
GO:0006886
GO:0006913
GO:0010494
GO:0016020
GO:0016441
GO:0016528
GO:0019901
GO:0031047
GO:0031410
GO:0032930
GO:0035198
GO:0035925
GO:0042803
GO:0043226
GO:0045727
GO:0048255
GO:0051260
GO:0060965
GO:0061157
GO:0065003
GO:0070935
GO:0098794
GO:0098978
GO:0106222
GO:1990904
GO:2000036
HMNXSV003012794
Hs.129572.0.A1_3p_at
Hs.184492.0.A1_3p_at
ILMN_1764873
PH_hs_0029372
TC19001125.hg
U38175_at
g13097227_3p_at
g4503550_3p_a_at
Participates
as an input of
p-S318,221-HuR binds mRNA (Homo sapiens)
as a component of
HuR with phosphoserine221 and phosphoserine318:mRNA Complex [nucleoplasm] (Homo sapiens)
as an output of
PKCdelta phosphorylates HuR (Homo sapiens)
Other forms of this molecule
ELAVL1 [nucleoplasm]
p-S158,S221-ELAVL1 [nucleoplasm]
ELAVL1 [cytosol]
p-S221,S318-ELAVL1 [cytosol]
p-S158,S221-ELAVL1 [cytosol]
Inferred To
phospho-Rbp9 [nucleoplasm]
(Drosophila melanogaster)
phospho-ELAVL1 [nucleoplasm]
(Bos taurus)
phospho-ELAVL1 [nucleoplasm]
(Canis familiaris)
phospho-ELAVL1 [nucleoplasm]
(Gallus gallus)
phospho-ELAVL1 [nucleoplasm]
(Sus scrofa)
phospho-Elavl1 [nucleoplasm]
(Mus musculus)
phospho-Elavl1 [nucleoplasm]
(Rattus norvegicus)
phospho-elav [nucleoplasm]
(Drosophila melanogaster)
phospho-fne [nucleoplasm]
(Drosophila melanogaster)
phospho-elavl1 [nucleoplasm]
(Xenopus tropicalis)
Homologues of p-S221,S318-ELAVL1 [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-serine at 221
Coordinate
221
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 318
Coordinate
318
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001410.2
OpenTargets
ENSG00000066044
ENSEMBL
ENST00000596459
,
ENSP00000472197
,
ENST00000407627
,
ENSP00000385269
HPA
ENSG00000066044-ELAVL1
ZINC - Substances
ELAV1_HUMAN
ZINC - Biogenic
ELAV1_HUMAN
ZINC target
Q15717
PRO
Q15717
Pharos - Targets
Q15717
GlyGen
Q15717
ZINC - Predictions - Purchasable
ELAV1_HUMAN
PDB
4FXV
,
6GD1
,
6GD2
,
4ED5
,
6GD3
,
6G2K
,
5SZW
,
6GC5
,
4EGL
,
3HI9
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54253 ATX1
0.666
7
UniProt:Q13148 TADBP
0.61
7
UniProt:P11387 TOP1
2
TOP1 [nucleoplasm]
(R-HSA-4641363)
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
0.597
4
UniProt:Q9NZI8 IGF2BP1
1
IGF2BP1 [cytosol]
(R-HSA-428366)
0.577
5
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.556
3
UniProt:Q15717 ELAVL1
6
ELAVL1 [nucleoplasm]
(R-HSA-450601)
p-S158,S221-ELAVL1 [nucleoplasm]
(R-HSA-450576)
p-S221,S318-ELAVL1 [nucleoplasm]
(R-HSA-450532)
ELAVL1 [cytosol]
(R-HSA-450582)
p-S221,S318-ELAVL1 [cytosol]
(R-HSA-450448)
p-S158,S221-ELAVL1 [cytosol]
(R-HSA-450376)
0.553
2
UniProt:Q99IB8-PRO_0000045602
0.547
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.527
2
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.527
4
IntAct:EBI-25438148 LNC
0.524
3
IntAct:EBI-20218130 CALM2
0.524
3
IntAct:EBI-20218183 CD9
0.524
3
UniProt:Q12906 ILF3
3
ILF3 [nucleoplasm]
(R-HSA-9760401)
ILF3 [cytosol]
(R-HSA-450564)
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
0.483
2
UniProt:P09651 HNRNPA1
2
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
HNRNPA1 [cytosol]
(R-HSA-9727902)
0.483
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
5
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.483
2
UniProt:Q8IUH3 RBM45
0.462
2
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