AUF1 binds translation and heat shock proteins

Stable Identifier
R-HSA-450551
Type
Reaction [binding]
Species
Homo sapiens
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Tetrameric AUF1 bound to RNA forms a complex with other proteins, including elongation factor eIF4G, polyA-binding protein PABP, Hsp, Hsc70, and Hsp27. AUF1 also directly interacts with polyadenylate.

Literature References
PubMed ID Title Journal Year
10205060 Control of mRNA decay by heat shock-ubiquitin-proteasome pathway

Laroia, G, Cuesta, R, Brewer, G, Schneider, RJ

Science 1999
16556936 Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay

Lu, JY, Bergman, N, Sadri, N, Schneider, RJ

RNA 2006
12819195 Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1

Wilson, GM, Lu, J, Sutphen, K, Sun, Y, Huynh, Y, Brewer, G

J Biol Chem 2003
18573886 Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay

Sinsimer, KS, Gratacos, FM, Knapinska, AM, Lu, J, Krause, CD, Wierzbowski, AV, Maher, LR, Scrudato, S, Rivera, YM, Gupta, S, Turrin, DK, De La Cruz, MP, Pestka, S, Brewer, G

Mol Cell Biol 2008
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