Reactome | AUF1 binds translation and heat shock proteins

AUF1 binds translation and heat shock proteins

Stable Identifier

R-HSA-450551

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

AUF1 binds translation and heat shock proteins

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Tetrameric AUF1 bound to RNA forms a complex with other proteins, including elongation factor eIF4G, polyA-binding protein PABP, Hsp, Hsc70, and Hsp27. AUF1 also directly interacts with polyadenylate.

Literature References

PubMed ID	Title	Journal	Year
16556936	Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay Schneider, RJ, Bergman, N, Sadri, N, Lu, JY	RNA	2006
10205060	Control of mRNA decay by heat shock-ubiquitin-proteasome pathway Brewer, G, Schneider, RJ, Laroia, G, Cuesta, R	Science	1999
12819195	Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1 Brewer, G, Wilson, GM, Huynh, Y, Sun, Y, Lu, J, Sutphen, K	J Biol Chem	2003
18573886	Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay Brewer, G, Sinsimer, KS, Krause, CD, Rivera, YM, Turrin, DK, Scrudato, S, Gupta, S, Wierzbowski, AV, Lu, J, Maher, LR, Knapinska, AM, Pestka, S, De La Cruz, MP, Gratacos, FM	Mol Cell Biol	2008