AUF1 (hnRNP D0) is ubiquitinylated

Stable Identifier
R-HSA-450580
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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AUF1 is ubiquitinated at unknown sites. The number of ubiquitin molecules conjugated to AUF1 and their linkage is unknown. Ubiquitination is required for subsequent degradation of both AUF1 and the mRNA bound by AUF1. It is uncertain if AUF1 is in a larger complex when it is ubiquitinated.

Literature References
PubMed ID Title Journal Year
10559216 Assembly of AUF1 oligomers on U-rich RNA targets by sequential dimer association

Wilson, GM, Sun, Y, Lu, H, Brewer, G

J Biol Chem 1999
12136087 Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms

Laroia, G, Schneider, RJ

Nucleic Acids Res 2002
11842200 Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs

Laroia, G, Sarkar, B, Schneider, RJ

Proc Natl Acad Sci U S A 2002
10205060 Control of mRNA decay by heat shock-ubiquitin-proteasome pathway

Laroia, G, Cuesta, R, Brewer, G, Schneider, RJ

Science 1999
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