Reactome | KSRP binds AU-rich element in 3' UTR of mRNA

KSRP binds AU-rich element in 3' UTR of mRNA

Stable Identifier

R-HSA-450592

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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KSRP binds AU-rich element in 3' UTR of mRNA

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KSRP (KHSRP) binds AU-rich regions of target RNAs via its four K-homology (KH) domains.

Literature References

PubMed ID	Title	Journal	Year
15514971	IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR Suswam, EA, Nabors, LB, Huang, Y, Yang, X, King, PH	Int J Cancer	2005
19141871	Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements Li, H, Chen, W, Zhou, Y, Abidi, P, Sharpe, O, Robinson, WH, Kraemer, FB, Liu, J	J Lipid Res	2009
19854161	Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes Schmidt, N, Pautz, A, Art, J, Rauschkolb, P, Jung, M, Erkel, G, Goldring, MB, Kleinert, H	Biochem Pharmacol	2010
18684992	The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets Garcia-Mayoral, MF, Diaz-Moreno, I, Hollingworth, D, Ramos, A	Nucleic Acids Res	2008
17177604	The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling Gherzi, R, Trabucchi, M, Ponassi, M, Ruggiero, T, Corte, G, Moroni, C, Chen, CY, Khabar, KS, Andersen, JS, Briata, P	PLoS Biol	2006