KSRP binds AU-rich element in 3' UTR of mRNA

Stable Identifier
Reaction [binding]
Homo sapiens
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KSRP (KHSRP) binds AU-rich regions of target RNAs via its four K-homology (KH) domains.

Literature References
PubMed ID Title Journal Year
19141871 Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements

Zhou, Y, Chen, W, Liu, J, Abidi, P, Sharpe, O, Li, H, Kraemer, FB, Robinson, WH

J Lipid Res 2009
15514971 IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR

Yang, X, Suswam, EA, Huang, Y, Nabors, LB, King, PH

Int J Cancer 2005
19854161 Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes

Kleinert, H, Rauschkolb, P, Art, J, Pautz, A, Jung, M, Goldring, MB, Erkel, G, Schmidt, N

Biochem Pharmacol 2010
18684992 The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets

Ramos, A, Garcia-Mayoral, MF, Diaz-Moreno, I, Hollingworth, D

Nucleic Acids Res 2008
17177604 The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling

Briata, P, Khabar, KS, Andersen, JS, Ruggiero, T, Trabucchi, M, Ponassi, M, Gherzi, R, Chen, CY, Moroni, C, Corte, G

PLoS Biol 2006
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