Reactome | KSRP binds AU-rich element in 3' UTR of mRNA

KSRP binds AU-rich element in 3' UTR of mRNA

Stable Identifier

R-HSA-450592

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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KSRP binds AU-rich element in 3' UTR of mRNA

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KSRP (KHSRP) binds AU-rich regions of target RNAs via its four K-homology (KH) domains.

Literature References

PubMed ID	Title	Journal	Year
19141871	Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements Zhou, Y, Chen, W, Liu, J, Abidi, P, Sharpe, O, Li, H, Kraemer, FB, Robinson, WH	J Lipid Res	2009
15514971	IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR Yang, X, Suswam, EA, Huang, Y, Nabors, LB, King, PH	Int J Cancer	2005
19854161	Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes Kleinert, H, Rauschkolb, P, Art, J, Pautz, A, Jung, M, Goldring, MB, Erkel, G, Schmidt, N	Biochem Pharmacol	2010
18684992	The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets Ramos, A, Garcia-Mayoral, MF, Diaz-Moreno, I, Hollingworth, D	Nucleic Acids Res	2008
17177604	The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling Briata, P, Khabar, KS, Andersen, JS, Ruggiero, T, Trabucchi, M, Ponassi, M, Gherzi, R, Chen, CY, Moroni, C, Corte, G	PLoS Biol	2006