HuR:mRNA complex translocates from the nucleus to the cytosol

Stable Identifier
R-HSA-450595
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

mRNA bound to HuR is exported from the nucleus by a mechanism that requires the shuttle protein APRIL but not pp32. Phosphorylation of APRIL determines its subcellular localization: APRIL phosphorylated at threonine244 is found in both the nucleus and cytoplasm while APRIL that is not phosphorylated at threonine244 is cytoplasmic.
HuR bound to mRNAs in the cytoplasm acts to stabilize the mRNAs by an unknown mechanism.

Literature References
PubMed ID Title Journal Year
17178712 Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression

Fries, B, Heukeshoven, J, Hauber, I, Grüttner, C, Stocking, C, Kehlenbach, RH, Hauber, J, Chemnitz, J

J Biol Chem 2007
19130553 Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression

Chemnitz, J, Pieper, D, Grüttner, C, Hauber, J

Eur J Immunol 2009
15257295 Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

Lal, A, Mazan-Mamczarz, K, Kawai, T, Yang, X, Martindale, JL, Gorospe, M

EMBO J 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!