KSRP (KHSRP) binds and destabilizes mRNA

Stable Identifier
R-HSA-450604
Type
Pathway
Species
Homo sapiens
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KSRP binds to AU-rich sequences in the 3' untranslated regions of mRNAs. KSRP causes the bound mRNA to be targeted for hydrolysis by recruiting exonucleases and decapping enzymes. The activity of KSRP is regulated by phosphorylation. Protein kinase B/Akt phosphorylates KSRP at serine193. The phosphorylation inhibits the ability of KSRP to destabilize mRNA. KSRP phosphorylated at serine193 binds 14-3-3zeta (YWHAZ) which causes KSRP to be retained in the nucleus.

Literature References
PubMed ID Title Journal Year
12704645 Post-transcriptional regulation of gene expression by degradation of messenger RNAs

Bevilacqua, A, Ceriani, MC, Capaccioli, S, Nicolin, A

J Cell Physiol 2003
16391004 AU-rich elements and associated factors: are there unifying principles?

Barreau, C, Paillard, L, Osborne, HB

Nucleic Acids Res 2005
12440953 AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors

Zhang, T, Kruys, V, Huez, G, Gueydan, C

Biochem Soc Trans 2002
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