isocitrate <=> citrate

Stable Identifier
R-HSA-450975
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
Expand all
Summation

Mitochondrial aconitase reversibly converts isocitrate to citrate via a cis-aconitate intermediate. Mitochondrial aconitase activity has been demonstrated in diverse human tissue extracts (Slaughter et al. 1975) and a protein homologous to the well-characterized porcine enzyme has been purified from human tissues (Baldwin et al. 1991).

Literature References
PubMed ID Title Journal Year
1052766 Aconitase polymorphism in man Ann Hum Genet 1975
1946331 Purification and partial amino acid sequence of human aconitase Protein Seq Data Anal 1991
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
aconitate hydratase activity of ACO2 [mitochondrial matrix]
Physical Entity
ACO2 [mitochondrial matrix]
Activity
aconitate hydratase activity (0003994)
Orthologous Events
isocitrate <=> citrate (Bos taurus)
isocitrate <=> citrate (Caenorhabditis elegans)
isocitrate <=> citrate (Canis familiaris)
isocitrate <=> citrate (Danio rerio)
isocitrate <=> citrate (Dictyostelium discoideum)
isocitrate <=> citrate (Drosophila melanogaster)
isocitrate <=> citrate (Gallus gallus)
isocitrate <=> citrate (Mus musculus)
isocitrate <=> citrate (Rattus norvegicus)
isocitrate <=> citrate (Saccharomyces cerevisiae)
isocitrate <=> citrate (Schizosaccharomyces pombe)
isocitrate <=> citrate (Sus scrofa)
isocitrate <=> citrate (Taeniopygia guttata)