Reactome | isocitrate <=> citrate

isocitrate <=> citrate

Stable Identifier

R-HSA-450975

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

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Mitochondrial aconitase reversibly converts isocitrate to citrate via a cis-aconitate intermediate. Mitochondrial aconitase activity has been demonstrated in diverse human tissue extracts (Slaughter et al. 1975) and a protein homologous to the well-characterized porcine enzyme has been purified from human tissues (Baldwin et al. 1991).

Literature References

PubMed ID	Title	Journal	Year
1052766	Aconitase polymorphism in man Slaughter, CA, Hopkinson, DA, Harris, H	Ann Hum Genet	1975
1946331	Purification and partial amino acid sequence of human aconitase Baldwin, GS, Seet, KL, Callaghan, J, Toncich, G, Toh, BH, Moritz, RL, Rubira, MR, Simpson, R	Protein Seq Data Anal	1991