isocitrate <=> citrate

Stable Identifier
R-HSA-450975
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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Mitochondrial aconitase reversibly converts isocitrate to citrate via a cis-aconitate intermediate. Mitochondrial aconitase activity has been demonstrated in diverse human tissue extracts (Slaughter et al. 1975) and a protein homologous to the well-characterized porcine enzyme has been purified from human tissues (Baldwin et al. 1991).

Literature References
PubMed ID Title Journal Year
1052766 Aconitase polymorphism in man

Slaughter, CA, Hopkinson, DA, Harris, H

Ann Hum Genet 1975
1946331 Purification and partial amino acid sequence of human aconitase

Baldwin, GS, Seet, KL, Callaghan, J, Toncich, G, Toh, BH, Moritz, RL, Rubira, MR, Simpson, R

Protein Seq Data Anal 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aconitate hydratase activity of ACO2 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Created