(S)-Malate <=> Fumarate + H2O

Stable Identifier
R-HSA-451033
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
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(S)-Malate <=> Fumarate + H2O
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Mitochondrial fumarate hydratase catalyzes the reversible reaction of malate to form fumarate and water (Bourgeron et al. 1994). Unpublished crystallographic data indicate that the protein is a tetramer (PDB 3E04).

Literature References
PubMed ID Title Journal Year
8200987 Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency

Bourgeron, T, Chretien, D, Poggi-Bach, J, Doonan, S, Rabier, D, Letouzé, P, Munnich, A, Rötig, A, Landrieu, P, Rustin, P

J Clin Invest 1994
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
Fumarate + H2O <=> (S)-Malate (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
fumarate hydratase activity of FH tetramer [mitochondrial matrix]
Physical Entity
FH tetramer [mitochondrial matrix]
Activity
fumarate hydratase activity (0004333)
Orthologous Events
(S)-Malate <=> Fumarate + H2O (Bos taurus)
(S)-Malate <=> Fumarate + H2O (Caenorhabditis elegans)
(S)-Malate <=> Fumarate + H2O (Canis familiaris)
(S)-Malate <=> Fumarate + H2O (Danio rerio)
(S)-Malate <=> Fumarate + H2O (Dictyostelium discoideum)
(S)-Malate <=> Fumarate + H2O (Drosophila melanogaster)
(S)-Malate <=> Fumarate + H2O (Gallus gallus)
(S)-Malate <=> Fumarate + H2O (Mus musculus)
(S)-Malate <=> Fumarate + H2O (Rattus norvegicus)
(S)-Malate <=> Fumarate + H2O (Saccharomyces cerevisiae)
(S)-Malate <=> Fumarate + H2O (Schizosaccharomyces pombe)
(S)-Malate <=> Fumarate + H2O (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-12-26)
Created
D'Eustachio, P  (2009-12-26)