Microtubule-independent trafficking of connexons to the plasma membrane

Stable Identifier
R-HSA-451056
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Connexons may also traffic using a microtubule-independent mechanism. A few studies suggest that rough ER membranes can directly transfer connexons to the plasma membrane (Martin et al. 2001; Bloom and Goldstein 1998). Other cytoskeletal components, such as actin filaments, might be involved in the delivery of connexons to gap junction plaques (Thomas et al. 2001; Gilleron et al. 2006).

Literature References
PubMed ID Title Journal Year
11719551 Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels

Martin, PE, Blundell, G, Ahmad, S, Errington, RJ, Evans, WH

J Cell Sci 2001
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