Activation of kainate receptors upon glutamate binding

Stable Identifier
R-HSA-451326
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Kainate receptors are found both in the presynaptc terminals and the postsynaptic neurons.
Kainate receptor activation could lead to either ionotropic activity (influx of Ca2+ or Na+ and K+) in the postsynaptic neuron or coupling of the receptor with G proteins in the presynaptic and the postsynaptic neurons.
Kainate receptors are tetramers made from subunits GRIK1-5 or GluR5-7 and KA1-2. Activation of kainate receptors made from GRIK1 or KA2 release Ca2+ from the intracellular stores in a G protein-dependent manner. The G protein involved in this process is sensitive to pertussis toxin.

Literature References
PubMed ID Title Journal Year
18793656 Kainate receptors: pharmacology, function and therapeutic potential

Jane, DE, Lodge, D, Collingridge, GL

Neuropharmacology 2009
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created