Activation of JNK by DSCAM

Stable Identifier
R-HSA-451347
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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DSCAM can stimulate the activation of JNK, one of the downstream events induced by activated PAK1. From the experiment using various dominant negative mutants it was suggested that PAK1 and MKK4 play a role in JNK activation.

Literature References
PubMed ID Title Journal Year
15169762 The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak

Li, W, Guan, KL

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of DSCAM:p-S144-PAK1:RAC1:GTP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created