Activation of p38MAPK by DSCAM

Stable Identifier
R-HSA-451366
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Its also observed that DSCAM can activate p38 MAP kinase along with JNK. Human DSCAM likely activates PAK1, JNK and p38 MAP kinase and these intracellular signaling events are similar to those activated by Drosophila Dscam. This suggests that the human DSCAM molecule may have physiological functions similar to Drosophila Dscam in axon guidance.

Literature References
PubMed ID Title Journal Year
15169762 The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak

Li, W, Guan, KL

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
MAP kinase activity of DSCAM:p-S144-PAK1:RAC1:GTP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created